mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2024.004mes-121Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHВзаимосвязь уровней гистамина, диаминоксидазы и субстанции P в сыворотке крови у пациентов с хронической крапивницейCorrelations between serum levels of histamine, diamine oxidase, substance P in patients with chronic urticariaМикрюковаН. В.MikryukovaN. V.

Наталья Васильевна Микрюкова

ул. Оптиков, д. 54, г. Санкт-Петербург, 197345

Natalya V. Mikryukova

Optikov, 54, Saint Petersburg, 197345

natalya@mikryukov.infoКалининаН. М.KalininaN. M.

Санкт-Петербург

Saint Petersburg

Всероссийский центр экстренной и радиационной медицины имени А. М. Никифорова МЧС РоссииРоссияNikiforov's All-Russian Center for Emergency and Radiation Medicine, EMERCOM of RussiaRussian FederationВсероссийский центр экстренной и радиационной медицины имени А. М. Никифорова МЧС России; Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова Минздрава РоссииРоссияNikiforov's All-Russian Center for Emergency and Radiation Medicine, EMERCOM of Russia; Pavlov First Saint Petersburg State Medical UniversityRussian Federation2024251020242618185Copyright © Микрюкова Н.В., Калинина Н.М., 20242024Микрюкова Н.В., Калинина Н.М.Mikryukova N.V., Kalinina N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/121

Возникновение и прогрессирование различных заболеваний, в том числе хронической крапивницы, связаны со стрессом. Ось кишечник-мозг-кожа используют для объяснения корреляций между состоянием нервной системы, желудочно-кишечного тракта, а также системным и местным воспалением в коже. В контексте оси кишечник-мозг-кожа мы обобщили воспалительные и иммунные механизмы хронической крапивницы и стресса. Целью нашего исследования было показать взаимосвязь между нейротрансмиттером субстанцией Р и диаминоксидазой, ферментом, разрушающим гистамин в кишечнике у пациентов, страдающих хронической крапивницей. В исследование было включено 165 взрослых людей от 18 до 68 лет, 97 пациентов страдали хронической крапивницей, группу сравнения составили 68 условно здоровых лиц. Методом ИФА (Cloud-Clone Corp; Китай) одновременно оценивали уровни субстанции Р, диаминоксидазы и гистамина в сыворотке крови. Была выявлена прямая заметная корреляционная связь (ρ = 0,5; p < 0,05) между субстанцией Р и диаминоксидазой у пациентов, страдающих хронической крапивницей, и в группе сравнения, что подтвердило наличие оси кишечник-мозг-кожа. В статье представлены теоретическая основа и новые цели для лечения хронической крапивницы. Обсуждена возможность предотвратить и лечить эти патологические состояния путем модуляции микробиоты кишечника, определены место диеты и изменения образа жизни, способствующие улучшению состояния здоровья в целом.

The onset and progression of various disorders, including chronic urticaria, are associated with stress. The gut-brain-skin axis is used to describe correlations among the nervous system, gastrointestinal tract states and systemic and skin inflammation. We have summarized inflammatory and immune mechanisms underlying chronic urticaria and stress in the context of the gut-brain-skin axis. The study was aimed to show the relationships between substance P, the neurotransmitter, and diamine oxidase, the enzyme disrupting histamine in the gut of patients suffering from chronic urticaria. A total of 165 adults aged 18–68 were enrolled; 97 patients had chronic urticaria, the comparison group was formed of 68 nominally healthy individuals. ELISA (Cloud-Clone Corp; China) was used to simultaneously estimate serum levels of substance P, diamine oxidase, and histamine. We revealed a significant positive correlation (ρ = 0.5; p < 0.05) between substance P and diamine oxidase in patients with chronic urticaria and in the comparison group, which confirmed the existence of the gut-brain-skin axis. The paper provides theoretical background and new targets for treatment of chronic urticaria. The possibility of prevention and treatment of these disorders by modulation of gut microbiota is discussed, the place of diet and the lifestyle modification contributing to improvement of general health are determined.

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The authors declare that there are no conflicts of interest present.