mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2023.020mes-155Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHВзаимосвязь вариантов иммунного реагирования с уровнем кортизола и адреналина при охлажденииThe relationship between the variants of immune response and the cortisol and adrenaline levels associated with coolingПатракееваВ. П.PatrakeevaV. P.

 Вероника Павловна Патракеевапр. Никольской, д. 20, г. Архангельск, 163020

Veronika P. PatrakeevaNikolsky prospect, 20, Arkhangelsk, 163020

atrakeewa.veronika@yandex.ruКонтиевскаяЕ. В.KontievskayaE. V.

Архангельск

Arkhangelsk

Институт физиологии природных адаптаций, Федеральный исследовательский центр комплексного изучения Арктики имени Н. П. Лаверова Уральского отделения Российской академии наукРоссияN. Laverov Federal Center for Integrated Arctic Research, Ural Branch of the Russian Academy of SciencesRussian Federation2023271020242525862Copyright © Патракеева В.П., Контиевская Е.В., 20242024Патракеева В.П., Контиевская Е.В.Patrakeeva V.P., Kontievskaya E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/155

Формирование адаптивной реакции в ответ на холодовое воздействие связано с повышением синтеза гормонов надпочечников, регулирующих функциональную и метаболическую активность иммунокомпетентных клеток. Варианты реагирования на холод могут значительно различаться даже у людей, длительное время проживающих на северных территориях. Целью работы было определить взаимосвязь фонового уровня кортизола и адреналина, а также изменения их концентрации при формировании адаптивной иммунной реакции в ответ на общее охлаждение. Обследовали 173 человека до и после кратковременного общего охлаждения. В периферической крови определены лейкограмма, уровень кортизола, адреналина и ферритина, наличие в лимфоцитах гликогена. Установлены три варианта реагирования: 1) относительно низкая фоновая концентрация кортизола и адреналина, без повышения их уровня после холодового воздействия не оказывает значимого влияния на миграционную активность лимфоцитов; 2) преимущественная активизация симпатико-адреналово-медуллярной оси связана с мобилизацией лимфоцитов в кровоток, при снижении их гликолитической активности; 3) более высокий фоновый уровень кортизола и дальнейшее повышение его концентрации до верхней границы нормы после охлаждения связаны с активизацией гликолиза в лимфоцитах и усилением их миграции в ткани.

The development of adaptive response to cold exposure is associated with the increased synthesis of the adrenal hormones involved in regulation of the immunocompetent cells’ functional and metabolic activity. Even people residing permanently in the North show different variants of response to cold. The study was aimed to determine the relationship between the baseline cortisol and adrenaline levels, as well as the changes in their concentrations associated with the adaptive immune response to whole body cooling. A total of 173 individuals were assessed before and after the short-term whole body cooling. White blood cell differential, cortisol, adrenaline and ferritin levels, and the presence of glycogen in lymphocytes were determined in peripheral blood. Three variants of response were defined: 1) the relatively low baseline levels of cortisol and adrenaline together with no increase in these levels after the cold exposure have no significant effect on the lymphocyte migration activity; 2) predominant activation of the sympathetic–adrenal–medullary axis is associated with lymphocyte mobilization into the bloodstream  along with the decrease in their glycolytic activity; 3) the higher baseline levels of cortisol and further increase in its concentration until it reaches the upper limit of the normal range following cooling are associated with intensification of glycolisis in lymphocytes and the increase of lymphocyte migration to the tissues.

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The authors declare that there are no conflicts of interest present.