mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2024-26-4-132-140mes-230Research ArticleГЕМАТОЛОГИЯНEMATOLOGYМикрочастицы как критерии качества концентрата тромбоцитовMicroparticles as quality criteria for platelet concentratehttps://orcid.org/0000-0003-4842-2504ГришинаГ. В.GrishinaG. V.

Гришина Галина Викторовна, канд. биол. наук, старший научный сотрудник НИЛ гемотрансфузионных технологий

Санкт-Петербург

St. Petersburg

reger201309@mail.ruhttps://orcid.org/0000-0002-3597-664XКасьяновА. Д.KasyanovA. D.

Касьянов Андрей Дмитриевич, канд. мед. наук, ведущий научный сотрудник НИЛ гемотрансфузионных технологий

Санкт-Петербург

St. Petersburg

bloodscience@mail.ruhttps://orcid.org/0000-0002-2727-1092ЛасточкинаД. В.LastochkinaD. V.

Ласточкина Дарья Вячеславовна

Санкт-Петербург

St. Petersburg

bloodscience@mail.ruhttps://orcid.org/0000-0002-6404-2387КробинецИ. И.KrobinetsI. I.

Кробинец Ирина Ивановна, д-р биол. наук, руководитель НИЛ иммуногенетики и диагностики иммунологических конфликтов

Санкт-Петербург

St. Petersburg

transfusion_spb@mail.ruhttps://orcid.org/0000-0002-1677-1956ГоловановаИ. С.GolovanovaI. S.

Голованова Ирина Станиславовна, научный сотрудник НИЛ гемотрансфузионных технологий

Санкт-Петербург

St. Petersburg

bloodscience@mail.ruhttps://orcid.org/0000-0003-2728-6590МатвиенкоО. Ю.MatvienkoO. Yu.

Матвиенко Олеся Юрьевна, канд. мед. наук, ведущий научный сотрудник научно-исследовательский отдел патологии гемостаза

Санкт-Петербург

St. Petersburg

bloodscience@mail.ruРоссийский научно-исследовательский институт гематологии и трансфузиологии Федерального медико-биологического агентстваРоссияRussian Research Institute of Hematology and TransfusiologyRussian Federation202407112024264132140Copyright © Гришина Г.В., Касьянов А.Д., Ласточкина Д.В., Кробинец И.И., Голованова И.С., Матвиенко О.Ю., 20242024Гришина Г.В., Касьянов А.Д., Ласточкина Д.В., Кробинец И.И., Голованова И.С., Матвиенко О.Ю.Grishina G.V., Kasyanov A.D., Lastochkina D.V., Krobinets I.I., Golovanova I.S., Matvienko O.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/230Введение

Введение. В связи с возросшей потребностью применения концентрата тромбоцитов для лечения и профилактики тромбоцитопатии актуальной задачей является разработка, совершенствование и внедрение новых подходов мониторинга параметров его качества и оценки безопасности.

Цель

Цель. Проведение систематического обзора и анализа литературных данных для выявления перспективных подходов к оценке адекватного анализа качества тромбоцитного концентрата для повышения эффективности и безопасности трансфузий.

Обсуждение

Обсуждение. Выявлены возможности и преимущества рационального подхода к переливанию концентрата тромбоцитов с учетом степени активации тромбоцитов для оптимизации заготовки компонента. Особое внимание уделено методам оценки активации тромбоцитов. Обнаружение микрочастиц на основе динамического рассеяния света позволит отличать активированные (с высоким содержанием микрочастиц) от неактивированных (с низким содержанием микрочастиц) тромбоцитов при проведении как лечебных, так и профилактических трансфузий и оптимизировать использование этого дефицитного компонента крови.

Выводы

Выводы. Возможность дифференцировки концентратов тромбоцитов на основе скрининга содержания микрочастиц, образующихся в результате активации, будет способствовать повышению эффективности и безопасности трансфузионной терапии.

Introduction

Introduction. Due to the increased requirement for platelet concentrate use in the treatment and prevention of thrombocytopathy, there is a pressing need for the development, improvement and implementation of new approaches to monitoring its quality parameters and safety assessment.

Objective

Objective. To conduct a systematic review and analysis of literature data, in order to identify promising approaches to evaluating an adequate analysis of the quality of platelet concentrate to improve the effectiveness and safety of transfusions.

Discussion

Discussion. The possibilities and advantages of a rational approach to platelet concentrate transfusion are established, while considering the degree of platelet activation required to optimize the preparation of the component. Special attention was paid to methods for evaluating platelet activation. The detection of microparticles based on dynamic light scattering will make it possible to distinguish activated platelets (with a high content of microparticles) from inactive (with a low content of microparticles) platelets during both therapeutic and preventive transfusions and optimize the use of this scarce blood component.

Conclusions

Conclusions. The ability to differentiate platelet concentrates based on the screening of the content of microparticles formed due to activation will contribute to improving the effectiveness and safety of transfusion therapy.

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The authors declare that there are no conflicts of interest present.