mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2025-288mes-288Research ArticleСПОРТИВНАЯ МЕДИЦИНАSPORTS MEDICINEВозможности применения отдельных метаболитов цикла трикарбоновых кислот у спортсменов (обзор литературы)Applicability of individual metabolites of the tricarboxylic acid cycle in athletes (A literature review)https://orcid.org/0000-0002-6015-4947ЯшинТ. А.YashinT. A.

Яшин Тимофей Александрович

Москва

Timofey A. Yashin

Moscow

yatim79@mail.ruhttps://orcid.org/0000-0002-9051-9580ГришинаЖ. В.GrishinaZh. V.

Гришина Жанна Валерьевна, канд. биол. наук

Москва

Zhanna V. Grishina, Cand. Sci. (Biol.)

Moscow

grinzanetk@gmail.comhttps://orcid.org/0000-0002-2281-9936ПарастаевС. А.ParastaevS. A.

Парастаев Сергей Андреевич, д-р мед. наук, профессор

Москва

Sergey A. Parastaev, Dr. Sci. (Med.), Professor

Moscow

parastaevsa@sportfmba.ruhttps://orcid.org/0000-0002-0267-9761ЖолинскийА. В.ZholinskyA. V.

Жолинский Андрей Владимирович, канд. мед. наук

Москва

Andrey V. Zholinsky, Cand. Sci. (Med.)

Moscow

ZholinskiiAV@sportfmba.ruФедеральный научно-клинический центр спортивной медицины и реабилитации Федерального медико-биологического агентстваРоссияFederal Research and Clinical Center of Sports Medicine and RehabilitationRussian Federation202526062025272249256Copyright © Яшин Т.А., Гришина Ж.В., Парастаев С.А., Жолинский А.В., 20252025Яшин Т.А., Гришина Ж.В., Парастаев С.А., Жолинский А.В.Yashin T.A., Grishina Z.V., Parastaev S.A., Zholinsky A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/288Введение

Введение. Многие метаболиты цикла трикарбоновых кислот (цикл Кребса, ЦТК) применяются в медицине. Развитие методов химического синтеза и удешевление производства отдельных метаболитов ЦТК делает их перспективными субстанциями для создания средств повышения адаптационного потенциала организма человека.

Цель

Цель. Выявление физиологических эффектов основных метаболитов ЦТК, позволяющих использовать продукцию на их основе для медико-биологического обеспечения спортсменов.

Обсуждение

Обсуждение. На основе анализа литературы изучены физиологические эффекты субстратов энергетического обмена — метаболитов ЦТК, которые применяются в спортивной медицине. В настоящее время нашли обоснованное применение сукцинат, цитрат, малат, оксалоацетат. В ряде исследований отмечался антикатаболический эффект альфа-кетоглутарата, но уровень доказательности его недостаточен. Перспективным для использования в спортивной медицине, но недостаточно изученным на настоящий момент является изоцитрат.

Выводы

Выводы. Физиологические эффекты большинства основных метаболитов ЦТК позволяют использовать продукцию на их основе в качестве антигипоксантов, антиоксидантов, нейропротекторов, средств коррекции метаболизма. Ряд метаболитов ЦТК являются перспективными субстанциями для создания новой продукции для медико-биологического обеспечения спортсменов, но их физиологические эффекты требуют дополнительного изучения. 

Introduction

Introduction. Various metabolites of the tricarboxylic acid cycle (Krebs cycle, TCA cycle, TCAC) find application in medicine. The emergence of improved chemical synthesis methods and the more affordable production of individual TCA metabolites make them promising candidates for developing effective compositions capable of increasing the adaptive potential of the human body.

Objective

Objective. Identification of the physiological effects of the main TCA metabolites. This knowledge is important for informed application of TCA metabolite-based products in the medical and biological support of athletes.

Discussion

Discussion. The conducted literature review investigated the physiological effects of TCA metabolites — energy metabolism substrates — used in sports medicine. At present, succinate, citrate, malate, and oxaloacetate have found reasonable use. A number of publications have reported the anti-catabolic effect of alpha-ketoglutarate; however, the current level of evidence is insufficient. Isocitrate dehydrogenase is promising for use in sports medicine, which substantiates its further detailed study.

Conclusions

Conclusions. Due to their physiological effects, the majority of TCA metabolites can be used in the compositions of antihypoxic, antioxidant, neuroprotector, and metabolic correction agents. A number of TCA metabolites are promising substances for creating new products for the medical and biological support of athletes, which validates additional research of their physiological effects.

цикл трикарбоновых кислотцикл Кребсатрикарбоновые кислотыэнергообменсубстраты энергетического обменаспорт высших достиженийантиоксидантыантигипоксантыизолимонная кислотаtricarboxylic acid cycleKrebs cycletricarboxylic acidsenergy metabolismenergy metabolism substrateshigh-performance sportantioxidantsantihypoxic agentsisocitric acidРабота выполнена в рамках прикладной НИР по теме «Возможности использования изолимонной кислоты и специализированной пищевой продукции на ее основе для улучшения энергетического баланса организма и повышения его адаптационных возможностей на фоне профессиональных спортивных нагрузок» (шифр «Энергобаланс-24»), государственный контракт ФГБУ ФНКЦСМ ФМБА России № 67.002.24.800 от 09.01.2024.The work was carried out within the framework of AR&D “Isocitric acid and specialized isocitric acid-based food products applicability to improve the body energy balance and increase its adaptive capabilities against the background of professional sports loads” (code Energobalance-24), state contract No.67.002.24.800 of 9 Jan. 2024.ReferencesGibala MJ, Peirce N, Constantin-Teodosiu D, Greenhaff PL. 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The authors declare that there are no conflicts of interest present.