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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mes</journal-id><journal-title-group><journal-title xml:lang="ru">Экстремальная биомедицина</journal-title><trans-title-group xml:lang="en"><trans-title>Extreme Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">3033-8964</issn><issn pub-type="epub">3033-8972</issn><publisher><publisher-name>Centre for Strategic Planning of the Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47183/mes.2024.015</article-id><article-id custom-type="elpub" pub-id-type="custom">mes-30</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Эссенциальный тремор: современный взгляд на проблему и новые возможности нейрохирургических методов лечения</article-title><trans-title-group xml:lang="en"><trans-title>Essential tremor: modern view of the problem and new neurosurgical treatment options</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катунина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Katunina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Анатольевна Катунина</p><p>Серпуховской вал, д. 17, г. Москва, 115191</p></bio><bio xml:lang="en"><p>Elena A. Katunina</p><p>Serpukhovskiy Val, 17, Moscow, 115191</p></bio><email xlink:type="simple">elkatunina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грязнев</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gryaznev</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шипилова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shipilova</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катунин</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Katunin</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малыхина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Malykhina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный центр мозга и нейротехнологий Федерального медико-биологического агентства; Российский национальный исследовательский медицинский университет имени Н. И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency; Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральный центр мозга и нейротехнологий Федерального медико-биологического агентства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>22</day><month>10</month><year>2024</year></pub-date><volume>26</volume><issue>1</issue><fpage>23</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Катунина Е.А., Грязнев Р.А., Шипилова Н.Н., Катунин Д.А., Малыхина Е.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Катунина Е.А., Грязнев Р.А., Шипилова Н.Н., Катунин Д.А., Малыхина Е.А.</copyright-holder><copyright-holder xml:lang="en">Katunina E.A., Gryaznev R.A., Shipilova N.N., Katunin D.A., Malykhina E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.extrememedicine.ru/jour/article/view/30">https://www.extrememedicine.ru/jour/article/view/30</self-uri><abstract><p>Обзор посвящен наиболее часто встречающемуся заболеванию экстрапирамидной системы — эссенциальному тремору (ЭТ). Приведены современные представления о патогенезе заболевания, затронуты вопросы классификации и дифференциального диагноза. Современные методы лечения ЭТ включают терапевтические подходы и хирургические вмешательства. Описаны преимущества нового перспективного метода лечения ЭТ — терапия фокусированным ультразвуком под контролем МРТ (ФУЗ-МРТ), обобщен имеющийся на сегодняшний день мировой опыт его применения, показания и противопоказания.</p></abstract><trans-abstract xml:lang="en"><p>The review is focused on essential tremor (ET), the most common extrapyramidal system disorder. Current understanding of the disease pathogenesis is provided; issues of classification and differential diagnosis are discussed. Modern ET treatment methods include therapeutic approaches and surgical interventions. The benefits of the new ET treatment method, the magnetic resonance-guided focused ultrasound treatment (MRgFUS), are described; the world’s experience of using the method, indications and contraindications are summarized.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эссенциальный тремор</kwd><kwd>лечение</kwd><kwd>диагностика</kwd><kwd>таламотомия</kwd><kwd>ФУЗ-МРТ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>essential tremor</kwd><kwd>treatment</kwd><kwd>diagnosis</kwd><kwd>thalamotomy</kwd><kwd>MRgFUS</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010; 25 (5): 534–41. DOI: 10.1002/mds.22838. PMID: 20175185.</mixed-citation><mixed-citation xml:lang="en">Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010; 25 (5): 534–41. DOI: 10.1002/mds.22838. PMID: 20175185.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bain PG, Findley LJ, Thompson PD, Gresty MA, Rothwell JC, Harding AE, et al. A study of hereditary essential tremor. Brain. 1994; 117 (Pt 4): 805–24. DOI: 10.1093/brain/117.4.805. PMID: 7922467.</mixed-citation><mixed-citation xml:lang="en">Bain PG, Findley LJ, Thompson PD, Gresty MA, Rothwell JC, Harding AE, et al. A study of hereditary essential tremor. Brain. 1994; 117 (Pt 4): 805–24. DOI: 10.1093/brain/117.4.805. PMID: 7922467.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, et al. Tremor Task Force of the International Parkinson and Movement Disorder Society. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018; 33 (1): 75–87. DOI: 10.1002/mds.27121. Epub 2017 Nov 30. PMID: 29193359; PMCID: PMC6530552.</mixed-citation><mixed-citation xml:lang="en">Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, et al. Tremor Task Force of the International Parkinson and Movement Disorder Society. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018; 33 (1): 75–87. DOI: 10.1002/mds.27121. Epub 2017 Nov 30. PMID: 29193359; PMCID: PMC6530552.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Иллариошкин С. Н., Иванова-Смоленская И. А. Дрожательные гиперкинезы: Руководство для врачей. Сер. руководств «Двигательные расстройства». М.: Атмосфера, 2011; 360 с.</mixed-citation><mixed-citation xml:lang="en">Illarioshkin SN, Ivanova-Smolenskaja IA. Drozhatel'nye giperkinezy: Rukovodstvo dlja vrachej. Ser. rukovodstv «Dvigatel'nye rasstrojstva». M.: Atmosfera, 2011; 360 s. Russian.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wider C, Ross OA, Wszolek ZK. Genetics of Parkinson disease and essential tremor. Curr Opin Neurol. 2010; 23 (4): 388–93. DOI: 10.1097/WCO.0b013e32833b1f4c. PMID: 20489616; PMCID: PMC3930090.</mixed-citation><mixed-citation xml:lang="en">Wider C, Ross OA, Wszolek ZK. Genetics of Parkinson disease and essential tremor. Curr Opin Neurol. 2010; 23 (4): 388–93. DOI: 10.1097/WCO.0b013e32833b1f4c. PMID: 20489616; PMCID: PMC3930090.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Louis ED, Clark LN, Ottman R. Familial versus Sporadic Essential Tremor: What Patterns Can One Decipher in Age of Onset? Neuroepidemiology. 2015; 44 (3): 166–72. DOI: 10.1159/000381807. Epub 2015 May 7. PMID: 25967236; PMCID: PMC4764084.</mixed-citation><mixed-citation xml:lang="en">Louis ED, Clark LN, Ottman R. Familial versus Sporadic Essential Tremor: What Patterns Can One Decipher in Age of Onset? Neuroepidemiology. 2015; 44 (3): 166–72. DOI: 10.1159/000381807. Epub 2015 May 7. PMID: 25967236; PMCID: PMC4764084.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Stefansson H, Steinberg S, Petursson H, Gustafsson O, Gudjonsdottir IH, Jonsdottir GA et al. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet. 2009; 41 (3): 277–9. DOI: 10.1038/ng.299. Epub 2009 Feb 1. Erratum in: Nat Genet. 2009; 41 (4): 504. PMID: 19182806; PMCID: PMC3740956.</mixed-citation><mixed-citation xml:lang="en">Stefansson H, Steinberg S, Petursson H, Gustafsson O, Gudjonsdottir IH, Jonsdottir GA et al. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet. 2009; 41 (3): 277–9. DOI: 10.1038/ng.299. Epub 2009 Feb 1. Erratum in: Nat Genet. 2009; 41 (4): 504. PMID: 19182806; PMCID: PMC3740956.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, Yuan Q, et al. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med. 2007; 13 (10): 1228–33. DOI: 10.1038/nm1664. Epub 2007 Sep 30. PMID: 17906634.</mixed-citation><mixed-citation xml:lang="en">Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, Yuan Q, et al. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med. 2007; 13 (10): 1228–33. DOI: 10.1038/nm1664. Epub 2007 Sep 30. PMID: 17906634.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, Robinson CA, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain. 2007; 130 (Pt12): 3297– 307. DOI: 10.1093/brain/awm266. Epub 2007 Nov 19. PMID: 18025031.</mixed-citation><mixed-citation xml:lang="en">Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, Robinson CA, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain. 2007; 130 (Pt12): 3297– 307. DOI: 10.1093/brain/awm266. Epub 2007 Nov 19. PMID: 18025031.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kuo SH, Wang J, Tate WJ, Pan MK, Kelly GC, Gutierrez J, et al. Cerebellar Pathology in Early Onset and Late Onset Essential Tremor. Cerebellum. 2017; 16 (2): 473–82. DOI: 10.1007/s12311-016-0826-5. PMID: 27726094; PMCID: PMC5336493.</mixed-citation><mixed-citation xml:lang="en">Kuo SH, Wang J, Tate WJ, Pan MK, Kelly GC, Gutierrez J, et al. Cerebellar Pathology in Early Onset and Late Onset Essential Tremor. Cerebellum. 2017; 16 (2): 473–82. DOI: 10.1007/s12311-016-0826-5. PMID: 27726094; PMCID: PMC5336493.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Long MA, Deans MR, Paul DL, Connors BW. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J Neurosci. 2002; 22 (24): 10898–905. DOI: 10.1523/JNEUROSCI.22-24-10898.2002. PMID: 12486184; PMCID: PMC2834587.</mixed-citation><mixed-citation xml:lang="en">Long MA, Deans MR, Paul DL, Connors BW. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J Neurosci. 2002; 22 (24): 10898–905. DOI: 10.1523/JNEUROSCI.22-24-10898.2002. PMID: 12486184; PMCID: PMC2834587.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Deuschl G, Petersen I, Lorenz D, Christensen K. Tremor in the elderly: Essential and aging-related tremor. Mov Disord. 2015; 30 (10): 1327–34. DOI: 10.1002/mds.26265. Epub 2015 Jun 22. PMID: 26095699; PMCID: PMC4779797.</mixed-citation><mixed-citation xml:lang="en">Deuschl G, Petersen I, Lorenz D, Christensen K. Tremor in the elderly: Essential and aging-related tremor. Mov Disord. 2015; 30 (10): 1327–34. DOI: 10.1002/mds.26265. Epub 2015 Jun 22. PMID: 26095699; PMCID: PMC4779797.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mu J, Carden WB, Kurukulasuriya NC, Alexander GM, Godwin DW. Ethanol influences on native T-type calcium current in thalamic sleep circuitry. J Pharmacol Exp Ther. 2003; 307 (1): 197–204. DOI: 10.1124/jpet.103.053272. Epub 2003 Jul 31. PMID: 12893844.</mixed-citation><mixed-citation xml:lang="en">Mu J, Carden WB, Kurukulasuriya NC, Alexander GM, Godwin DW. Ethanol influences on native T-type calcium current in thalamic sleep circuitry. J Pharmacol Exp Ther. 2003; 307 (1): 197–204. DOI: 10.1124/jpet.103.053272. Epub 2003 Jul 31. PMID: 12893844.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hedera P. Emerging strategies in the management of essential tremor. Ther Adv Neurol Disord. 2017; 10 (2): 137–48. DOI: 10.1177/1756285616679123. Epub 2016 Nov 30. PMID: 28382111; PMCID: PMC5367648.</mixed-citation><mixed-citation xml:lang="en">Hedera P. Emerging strategies in the management of essential tremor. Ther Adv Neurol Disord. 2017; 10 (2): 137–48. DOI: 10.1177/1756285616679123. Epub 2016 Nov 30. PMID: 28382111; PMCID: PMC5367648.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rajalingam R, Breen DP, Lang AE, Fasano A. Essential tremor plus is more common than essential tremor: Insights from the reclassification of a cohort of patients with lower limb tremor. Parkinsonism Relat Disord. 2018; 56: 109–10. DOI: 10.1016/j.parkreldis.2018.06.029. Epub 2018 Jun 21. PMID: 29958776.</mixed-citation><mixed-citation xml:lang="en">Rajalingam R, Breen DP, Lang AE, Fasano A. Essential tremor plus is more common than essential tremor: Insights from the reclassification of a cohort of patients with lower limb tremor. Parkinsonism Relat Disord. 2018; 56: 109–10. DOI: 10.1016/j.parkreldis.2018.06.029. Epub 2018 Jun 21. PMID: 29958776.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Elble RJ. Do We Belittle Essential Tremor by Calling It a Syndrome Rather Than a Disease? No. Front Neurol. 2020; 11: 586606. DOI: 10.3389/fneur.2020.586606. PMID: 33101188; PMCID: PMC7554602.</mixed-citation><mixed-citation xml:lang="en">Elble RJ. Do We Belittle Essential Tremor by Calling It a Syndrome Rather Than a Disease? No. Front Neurol. 2020; 11: 586606. DOI: 10.3389/fneur.2020.586606. PMID: 33101188; PMCID: PMC7554602.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Louis ED, Huey ED, Cosentino S. Features of "ET plus" correlate with age and tremor duration: "ET plus" may be a disease stage rather than a subtype of essential tremor. Parkinsonism Relat Disord. 2021; 91: 42–47. DOI: 10.1016/j.parkreldis.2021.08.017. Epub 2021 Sep 1. PMID: 34482193.</mixed-citation><mixed-citation xml:lang="en">Louis ED, Huey ED, Cosentino S. Features of "ET plus" correlate with age and tremor duration: "ET plus" may be a disease stage rather than a subtype of essential tremor. Parkinsonism Relat Disord. 2021; 91: 42–47. DOI: 10.1016/j.parkreldis.2021.08.017. Epub 2021 Sep 1. PMID: 34482193.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gionco JT, Hartstone WG, Martuscello RT, Kuo SH, Faust PL, Louis ED. Essential Tremor versus "ET-plus": A Detailed Postmortem Study of Cerebellar Pathology. Cerebellum. 2021; 20 (6): 904–12. DOI: 10.1007/s12311-021-01263-6. Epub 2021 Mar 25. PMID: 33768479; PMCID: PMC8972074.</mixed-citation><mixed-citation xml:lang="en">Gionco JT, Hartstone WG, Martuscello RT, Kuo SH, Faust PL, Louis ED. Essential Tremor versus "ET-plus": A Detailed Postmortem Study of Cerebellar Pathology. Cerebellum. 2021; 20 (6): 904–12. DOI: 10.1007/s12311-021-01263-6. Epub 2021 Mar 25. PMID: 33768479; PMCID: PMC8972074.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Iglesias-Hernandez D, Delgado N, McGurn M, Huey ED, Cosentino S, Louis ED. "ET Plus": Instability of the Diagnosis During Prospective Longitudinal Follow-up of Essential Tremor Cases. Front Neurol. 2021; 12: 782694. DOI: 10.3389/fneur.2021.782694. PMID: 34975736; PMCID: PMC8716461.</mixed-citation><mixed-citation xml:lang="en">Iglesias-Hernandez D, Delgado N, McGurn M, Huey ED, Cosentino S, Louis ED. "ET Plus": Instability of the Diagnosis During Prospective Longitudinal Follow-up of Essential Tremor Cases. Front Neurol. 2021; 12: 782694. DOI: 10.3389/fneur.2021.782694. PMID: 34975736; PMCID: PMC8716461.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Erro R, Fasano A, Barone P, Bhatia KP. Milestones in Tremor Research: 10 Years Later. Mov Disord Clin Pract. 2022; 9 (4): 429–35. DOI: 10.1002/mdc3.13418. PMID: 35582314; PMCID: PMC9092753.</mixed-citation><mixed-citation xml:lang="en">Erro R, Fasano A, Barone P, Bhatia KP. Milestones in Tremor Research: 10 Years Later. Mov Disord Clin Pract. 2022; 9 (4): 429–35. DOI: 10.1002/mdc3.13418. PMID: 35582314; PMCID: PMC9092753.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Benito-León J, Louis ED, Bermejo-Pareja F. Neurological disorders in central spain study group. Elderly-onset essential tremor is associated with dementia. Neurology. 2006; 66 (10): 1500–5. DOI: 10.1212/01.wnl.0000216134.88617.de. PMID: 16717208.</mixed-citation><mixed-citation xml:lang="en">Benito-León J, Louis ED, Bermejo-Pareja F. Neurological disorders in central spain study group. Elderly-onset essential tremor is associated with dementia. Neurology. 2006; 66 (10): 1500–5. DOI: 10.1212/01.wnl.0000216134.88617.de. PMID: 16717208.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Huang H, Yang X, Zhao Q, Chen Y, Ning P, Shen Q, et al. Prevalence and risk Ffctors of depression and anxiety in essential tremor patients: a cross-sectional study in Southwest China. Front Neurol. 2019; 10: 1194. DOI: 10.3389/fneur.2019.01194. PMID: 31803131; PMCID: PMC6873801.</mixed-citation><mixed-citation xml:lang="en">Huang H, Yang X, Zhao Q, Chen Y, Ning P, Shen Q, et al. Prevalence and risk Ffctors of depression and anxiety in essential tremor patients: a cross-sectional study in Southwest China. Front Neurol. 2019; 10: 1194. DOI: 10.3389/fneur.2019.01194. PMID: 31803131; PMCID: PMC6873801.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hedera P, Cibulčík F, Davis TL. Pharmacotherapy of essential tremor. J Cent Nerv Syst Dis. 2013; 5: 43–55. DOI: 10.4137/JCNSD.S6561. PMID: 24385718; PMCID: PMC3873223.</mixed-citation><mixed-citation xml:lang="en">Hedera P, Cibulčík F, Davis TL. Pharmacotherapy of essential tremor. J Cent Nerv Syst Dis. 2013; 5: 43–55. DOI: 10.4137/JCNSD.S6561. PMID: 24385718; PMCID: PMC3873223.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Deuschl G, Raethjen J, Hellriegel H, Elble R. Treatment of patients with essential tremor. Lancet Neurol. 2011; 10 (2): 148–61. DOI: 10.1016/S1474-4422(10)70322-7. PMID: 21256454.</mixed-citation><mixed-citation xml:lang="en">Deuschl G, Raethjen J, Hellriegel H, Elble R. Treatment of patients with essential tremor. Lancet Neurol. 2011; 10 (2): 148–61. DOI: 10.1016/S1474-4422(10)70322-7. PMID: 21256454.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Zesiewicz TA, Elble R, Louis ED, Hauser RA, Sullivan KL, Dewey RB Jr, et al. Quality standards subcommittee of the american academy of neurology. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2005; 64 (12): 2008–20. DOI: 10.1212/01.WNL.0000163769.28552.CD. Epub 2005 Jun 22. PMID: 15972843.</mixed-citation><mixed-citation xml:lang="en">Zesiewicz TA, Elble R, Louis ED, Hauser RA, Sullivan KL, Dewey RB Jr, et al. Quality standards subcommittee of the american academy of neurology. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2005; 64 (12): 2008–20. DOI: 10.1212/01.WNL.0000163769.28552.CD. Epub 2005 Jun 22. PMID: 15972843.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira JJ, Mestre TA, Lyons KE, Benito-León J, Tan EK, Abbruzzese G, et al. MDS task force on tremor and the MDS evidence based medicine committee. MDS evidence-based review of treatments for essential tremor. Mov Disord. 2019; 34 (7): 950–8. DOI: 10.1002/mds.27700. Epub 2019 May 2. PMID: 31046186.</mixed-citation><mixed-citation xml:lang="en">Ferreira JJ, Mestre TA, Lyons KE, Benito-León J, Tan EK, Abbruzzese G, et al. MDS task force on tremor and the MDS evidence based medicine committee. MDS evidence-based review of treatments for essential tremor. Mov Disord. 2019; 34 (7): 950–8. DOI: 10.1002/mds.27700. Epub 2019 May 2. PMID: 31046186.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Koller W, Biary N, Cone S. Disability in essential tremor: effect of treatment. Neurology. 1986; 36 (7): 1001–4. DOI: 10.1212/wnl.36.7.1001. PMID: 2940473.</mixed-citation><mixed-citation xml:lang="en">Koller W, Biary N, Cone S. Disability in essential tremor: effect of treatment. Neurology. 1986; 36 (7): 1001–4. DOI: 10.1212/wnl.36.7.1001. PMID: 2940473.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Zesiewicz TA, Elble RJ, Louis ED, Gronseth GS, Ondo WG, Dewey RB Jr, et al. Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology. Neurology. 2011; 77 (19): 1752–5. DOI: 10.1212/WNL.0b013e318236f0fd. Epub 2011 Oct 19. PMID: 22013182; PMCID: PMC3208950.</mixed-citation><mixed-citation xml:lang="en">Zesiewicz TA, Elble RJ, Louis ED, Gronseth GS, Ondo WG, Dewey RB Jr, et al. Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology. Neurology. 2011; 77 (19): 1752–5. DOI: 10.1212/WNL.0b013e318236f0fd. Epub 2011 Oct 19. PMID: 22013182; PMCID: PMC3208950.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Flora ED, Perera CL, Cameron AL, Maddern GJ. Deep brain stimulation for essential tremor: a systematic review. Mov Disord. 2010; 25 (11): 1550–9. DOI: 10.1002/mds.23195. PMID: 20623768.</mixed-citation><mixed-citation xml:lang="en">Flora ED, Perera CL, Cameron AL, Maddern GJ. Deep brain stimulation for essential tremor: a systematic review. Mov Disord. 2010; 25 (11): 1550–9. DOI: 10.1002/mds.23195. PMID: 20623768.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Verla T, Marky A, Farber H, Petraglia FW 3rd, Gallis J, Lokhnygina Y, et al. Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor. J Clin Neurosci. 2015; 22 (5): 872–6. DOI: 10.1016/j.jocn.2014.11.005. Epub 2015 Feb 7. PMID: 25669119; PMCID: PMC4512238.</mixed-citation><mixed-citation xml:lang="en">Verla T, Marky A, Farber H, Petraglia FW 3rd, Gallis J, Lokhnygina Y, et al. Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor. J Clin Neurosci. 2015; 22 (5): 872–6. DOI: 10.1016/j.jocn.2014.11.005. Epub 2015 Feb 7. PMID: 25669119; PMCID: PMC4512238.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Favilla CG, Ullman D, Wagle Shukla A, Foote KD, Jacobson CE 4th, Okun MS. Worsening essential tremor following deep brain stimulation: disease progression versus tolerance. Brain. 2012; 135 (Pt 5): 1455–62. DOI: 10.1093/brain/aws026. Epub 2012 Feb 17. PMID: 22344584.</mixed-citation><mixed-citation xml:lang="en">Favilla CG, Ullman D, Wagle Shukla A, Foote KD, Jacobson CE 4th, Okun MS. Worsening essential tremor following deep brain stimulation: disease progression versus tolerance. Brain. 2012; 135 (Pt 5): 1455–62. DOI: 10.1093/brain/aws026. Epub 2012 Feb 17. PMID: 22344584.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Frighetto L, Bizzi J, Oppitz P. Stereotactic radiosurgery for movement disorders. Surg Neurol Int. 2012; 3 (Supple 1): S10–6. DOI: 10.1007/978-3-642-11151-8_18.</mixed-citation><mixed-citation xml:lang="en">Frighetto L, Bizzi J, Oppitz P. Stereotactic radiosurgery for movement disorders. Surg Neurol Int. 2012; 3 (Supple 1): S10–6. DOI: 10.1007/978-3-642-11151-8_18.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Agrawal M, Garg K, Samala R, Rajan R, Naik V, Singh M. Outcome and complications of MR guided focused ultrasound for essential tremor: a systematic review and meta-analysis. Front Neurol. 2021; 12: 654711. DOI: 10.3389/fneur.2021.654711. PMID: 34025558; PMCID: PMC8137896.</mixed-citation><mixed-citation xml:lang="en">Agrawal M, Garg K, Samala R, Rajan R, Naik V, Singh M. Outcome and complications of MR guided focused ultrasound for essential tremor: a systematic review and meta-analysis. Front Neurol. 2021; 12: 654711. DOI: 10.3389/fneur.2021.654711. PMID: 34025558; PMCID: PMC8137896.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gallay MN, Moser D, Rossi F, Pourtehrani P, Magara AE, Kowalski M, et al. Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy. J Ther Ultrasound. 2016; 4: 5. DOI: 10.1186/s40349-016-0049-8. PMID: 26877873; PMCID: PMC4752806.</mixed-citation><mixed-citation xml:lang="en">Gallay MN, Moser D, Rossi F, Pourtehrani P, Magara AE, Kowalski M, et al. Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy. J Ther Ultrasound. 2016; 4: 5. DOI: 10.1186/s40349-016-0049-8. PMID: 26877873; PMCID: PMC4752806.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Титова Н. В., Катунина Е. А., Таирова Р. Т., Сенько И. В., Джафаров В. М., Малыхина Е. А. Фармакорезистентный тремор при болезни Паркинсона и эссенциальном треморе. Журнал неврологии и психиатрии им. С. С. Корсакова. 2022; 122 (10): 24–30. DOI: 10.17116/jnevro202212210124. PMID: 36279225.</mixed-citation><mixed-citation xml:lang="en">Titova NV, Katunina EA, Tairova RT, Senko IV, Dzhafarov VM, Malyhina EA. Farmakorezistentnyj tremor pri bolezni Parkinsona i jessencial'nom tremore. Zhurnal nevrologii i psihiatrii im. S. S. Korsakova. 2022; 122 (10): 24–30. DOI: 10.17116/jnevro202212210124. PMID: 36279225. Russian.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Elias WJ, Huss D, Voss T, Loomba J, Khaled M, Zadicario E, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2013; 369 (7): 640–8. DOI: 10.1056/NEJMoa1300962. PMID: 23944301.</mixed-citation><mixed-citation xml:lang="en">Elias WJ, Huss D, Voss T, Loomba J, Khaled M, Zadicario E, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2013; 369 (7): 640–8. DOI: 10.1056/NEJMoa1300962. PMID: 23944301.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2016; 375 (8): 730–9. DOI: 10.1056/NEJMoa1600159. PMID: 27557301.</mixed-citation><mixed-citation xml:lang="en">Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2016; 375 (8): 730–9. DOI: 10.1056/NEJMoa1600159. PMID: 27557301.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Halpern CH, Santini V, Lipsman N, Lozano AM, Schwartz ML, Shah BB, et al. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor. Neurology. 2019; 93 (24): e2284-e2293. DOI: 10.1212/WNL.0000000000008561. Epub 2019 Nov 20. PMID: 31748250.</mixed-citation><mixed-citation xml:lang="en">Halpern CH, Santini V, Lipsman N, Lozano AM, Schwartz ML, Shah BB, et al. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor. Neurology. 2019; 93 (24): e2284-e2293. DOI: 10.1212/WNL.0000000000008561. Epub 2019 Nov 20. PMID: 31748250.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Sinai A, Nassar M, Eran A, Constantinescu M, Zaaroor M, Sprecher E, et al. Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience. J Neurosurg. 2019: 1–8. DOI: 10.3171/2019.3.JNS19466. Epub ahead of print. PMID: 31277064.</mixed-citation><mixed-citation xml:lang="en">Sinai A, Nassar M, Eran A, Constantinescu M, Zaaroor M, Sprecher E, et al. Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience. J Neurosurg. 2019: 1–8. DOI: 10.3171/2019.3.JNS19466. Epub ahead of print. PMID: 31277064.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Schreglmann SR, Bauer R, Hägele-Link S, Bhatia KP, Natchev P, Wegener N, et al. Unilateral cerebellothalamic tract ablation in essential tremor by MRI-guided focused ultrasound. Neurology. 2017; 88 (14): 1329–33. DOI: 10.1212/WNL.0000000000003795. Epub 2017 Mar 8. PMID: 28275083.</mixed-citation><mixed-citation xml:lang="en">Schreglmann SR, Bauer R, Hägele-Link S, Bhatia KP, Natchev P, Wegener N, et al. Unilateral cerebellothalamic tract ablation in essential tremor by MRI-guided focused ultrasound. Neurology. 2017; 88 (14): 1329–33. DOI: 10.1212/WNL.0000000000003795. Epub 2017 Mar 8. PMID: 28275083.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Mohammed N, Patra D, Nanda A. A meta-analysis of outcomes and complications of magnetic resonance-guided focused ultrasound in the treatment of essential tremor. Neurosurg Focus. 2018; 44 (2): E4. DOI: 10.3171/2017.11.FOCUS17628. Erratum in: Neurosurg Focus. 2018; 45 (1): E16. PMID: 29385917.</mixed-citation><mixed-citation xml:lang="en">Mohammed N, Patra D, Nanda A. A meta-analysis of outcomes and complications of magnetic resonance-guided focused ultrasound in the treatment of essential tremor. Neurosurg Focus. 2018; 44 (2): E4. DOI: 10.3171/2017.11.FOCUS17628. Erratum in: Neurosurg Focus. 2018; 45 (1): E16. PMID: 29385917.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Park YS, Jung NY, Na YC, Chang JW. Four-year follow-up results of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. Mov Disord. 2019; 34 (5): 727–34. DOI: 10.1002/mds.27637. Epub 2019 Feb 13. PMID: 30759322.</mixed-citation><mixed-citation xml:lang="en">Park YS, Jung NY, Na YC, Chang JW. Four-year follow-up results of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. Mov Disord. 2019; 34 (5): 727–34. DOI: 10.1002/mds.27637. Epub 2019 Feb 13. PMID: 30759322.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Gasca-Salas C, Guida P, Piredda R, Obeso I, Vela Desojo L, Martínez-Fernández R, et al. Cognitive safety after unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. J Neurol Neurosurg Psychiatry. 2019; 90 (7): 830–1. DOI: 10.1136/jnnp-2018-320129. Epub 2019 Mar 8. PMID: 30850471.</mixed-citation><mixed-citation xml:lang="en">Gasca-Salas C, Guida P, Piredda R, Obeso I, Vela Desojo L, Martínez-Fernández R, et al. Cognitive safety after unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. J Neurol Neurosurg Psychiatry. 2019; 90 (7): 830–1. DOI: 10.1136/jnnp-2018-320129. Epub 2019 Mar 8. PMID: 30850471.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Rohringer CR, Sewell IJ, Gandhi S, Isen J, Davidson B, McSweeney M, et al. Cognitive effects of unilateral thalamotomy for tremor: a meta-analysis. Brain Commun. 2022; 4 (6): fcac287. DOI: 10.1093/braincomms/fcac287. PMID: 36440102; PMCID: PMC9683603.</mixed-citation><mixed-citation xml:lang="en">Rohringer CR, Sewell IJ, Gandhi S, Isen J, Davidson B, McSweeney M, et al. Cognitive effects of unilateral thalamotomy for tremor: a meta-analysis. Brain Commun. 2022; 4 (6): fcac287. DOI: 10.1093/braincomms/fcac287. PMID: 36440102; PMCID: PMC9683603.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Young RF, Hesselgesser RD, Ahn E, Vermeulen S, Li F, Lee J. Bilateral Gamma Knife thalamotomy for treatment of axial tremor. Transl Cancer Res. 2014; 3 (6): 525–9. DOI: 10.3978/j.issn.2218-676X.2014.11.01.</mixed-citation><mixed-citation xml:lang="en">Young RF, Hesselgesser RD, Ahn E, Vermeulen S, Li F, Lee J. Bilateral Gamma Knife thalamotomy for treatment of axial tremor. Transl Cancer Res. 2014; 3 (6): 525–9. DOI: 10.3978/j.issn.2218-676X.2014.11.01.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Iorio-Morin C, Yamamoto K, Sarica C, Zemmar A, Levesque M, Brisebois S, et al. Bilateral focused ultrasound thalamotomy for essential tremor (BEST-FUS Phase 2 Trial). Mov Disord. 2021; 36 (11): 2653–62. DOI: 10.1002/mds.28716. Epub 2021 Jul 20. PMID: 34288097.</mixed-citation><mixed-citation xml:lang="en">Iorio-Morin C, Yamamoto K, Sarica C, Zemmar A, Levesque M, Brisebois S, et al. Bilateral focused ultrasound thalamotomy for essential tremor (BEST-FUS Phase 2 Trial). Mov Disord. 2021; 36 (11): 2653–62. DOI: 10.1002/mds.28716. Epub 2021 Jul 20. PMID: 34288097.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Fukutome K, Hirabayashi H, Osakada Y, Kuga Y, Ohnishi H. Bilateral magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor. stereotact funct neurosurg. 2022; 100 (1): 44–52. DOI: 10.1159/000518662. Epub 2021 Sep 7. PMID: 34515233.</mixed-citation><mixed-citation xml:lang="en">Fukutome K, Hirabayashi H, Osakada Y, Kuga Y, Ohnishi H. Bilateral magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor. stereotact funct neurosurg. 2022; 100 (1): 44–52. DOI: 10.1159/000518662. Epub 2021 Sep 7. PMID: 34515233.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Scantlebury N, Rohringer CR, Rabin JS, Yunusova Y, Huang Y, Jones RM, et al. Safety of bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. Mov Disord Clin Pract. 2023; 10 (10): 1559–61. DOI: 10.1002/mdc3.13882. PMID: 37868927; PMCID: PMC10585969.</mixed-citation><mixed-citation xml:lang="en">Scantlebury N, Rohringer CR, Rabin JS, Yunusova Y, Huang Y, Jones RM, et al. Safety of bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. Mov Disord Clin Pract. 2023; 10 (10): 1559–61. DOI: 10.1002/mdc3.13882. PMID: 37868927; PMCID: PMC10585969.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Gallay MN, Moser D, Jeanmonod D. MR-guided focused ultrasound cerebellothalamic tractotomy for chronic therapyresistant essential tremor: anatomical target reappraisal and clinical results. J Neurosurg. 2020; 134 (2): 376–85. DOI: 10.3171/2019.12.JNS192219. PMID: 32032945.</mixed-citation><mixed-citation xml:lang="en">Gallay MN, Moser D, Jeanmonod D. MR-guided focused ultrasound cerebellothalamic tractotomy for chronic therapyresistant essential tremor: anatomical target reappraisal and clinical results. J Neurosurg. 2020; 134 (2): 376–85. DOI: 10.3171/2019.12.JNS192219. PMID: 32032945.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Vetkas A, Boutet A, Sarica C, Germann J, Gwun D, Yamamoto K, et al. Successful magnetic resonance-guided focused ultrasound treatment of tremor in patients with a skull density ratio of 0.4 or less. J Neurosurg. 2023; 1: 1–9. DOI: 10.3171/2023.6.JNS23171. Epub ahead of print. PMID: 37657095.</mixed-citation><mixed-citation xml:lang="en">Vetkas A, Boutet A, Sarica C, Germann J, Gwun D, Yamamoto K, et al. Successful magnetic resonance-guided focused ultrasound treatment of tremor in patients with a skull density ratio of 0.4 or less. J Neurosurg. 2023; 1: 1–9. DOI: 10.3171/2023.6.JNS23171. Epub ahead of print. PMID: 37657095.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
