mesЭкстремальная биомедицинаExtreme Medicine2713-27572713-2765Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2025-318mes-318Research ArticleКЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯCLINICAL PHARMACOLOGYОценка устойчивости Acinetobacter baumannii in vitro к тигециклину в Иране: систематический обзор и метаанализIn vitro evaluation of Acinetobacter baumannii resistance to tigecycline in Iran: a systematic review and meta-analysishttps://orcid.org/0000-0002-0024-1934РахманянМ.RahmanianMohammad

Мохаммад Рахманян

Тегеран

Mohammad Rahmanian, Student Research Committee,School of Medicine

Tehran

mmdrahmanian@gmail.comhttps://orcid.org/0009-0002-5369-6323ВаржовиМ. Н.VarjoviMahdiyeh Nozad

Махдия Нозад Варжови

Тебриз

Mahdiyeh Nozad Varjovi, Student research committee

Tabriz

m.nozad1998@gmail.comhttps://orcid.org/0000-0002-6965-6927ДеравиН.DeraviNiloofar

Нилуфар Дерави

Тегеран

Niloofar Deravi, Student Research Committee, School ofMedicine

Tehran

niloofar.deravi@gmail.comhttps://orcid.org/0000-0003-4757-7563НариманЗ.NarimanZahra

Зара Нариман

Тегеран

Zahra Nariman, School of Medicine

Tehran

zahranariman1377@gmail.comhttps://orcid.org/0000-0003-4251-8222ГоламзадА.GholamzadAmir

Амир Голамзад

Тегеран

Amir Gholamzad, Department of Laboratory Medicine(Faculty of Paramedical Sciences), Department ofMicrobiology and Immunology (Faculty of Medicine), TehranMedical Sciences

Tehran

96consultancy@gmail.comhttps://orcid.org/0000-0003-0246-6042КайланиК.KeylaniKimia

Кимия Кайлани

Тегеран

 

Kimia Keylani, School of Pharmacy

Tehran

keylani.kimia@gmail.comhttps://orcid.org/0000-0002-5421-1722АлизадеА.AlizadehAlaleh

Алалех Ализаде

Мешхед

Alaleh Alizadeh, Student Research Committee, Faculty ofMedicine, Mashhad Branch

Mashhad

alalizdh@gmail.comhttps://orcid.org/0009-0005-4853-3425Мусави-ан-фардС. Р.MousavianfardSeyed Reza

Сейед Реза Мусави-ан-фард

Тегеран

Seyed Reza Mousavianfard, Student ResearchCommittee, School of Dentistry

Tehran

dr.s.rezamousavianfard@gmail.comУниверситет медицинских наук Шахид БехештиИранShahid Beheshti University of Medical SciencesIslamic Republic of IranТебризский университет медицинских наукИранTabriz University of Medical SciencesIslamic Republic of IranИсламский университет АзадИранIslamic Azad UniversityIslamic Republic of IranИсламский университет АзадИранMashhad Branch, Islamic Azad UniversityIslamic Republic of Iran202526062025272257266Copyright © Рахманян М., Варжови М.Н., Дерави Н., Нариман З., Голамзад А., Кайлани К., Ализаде А., Мусави-ан-фард С.Р., 20252025Рахманян М., Варжови М.Н., Дерави Н., Нариман З., Голамзад А., Кайлани К., Ализаде А., Мусави-ан-фард С.Р.Rahmanian M., Varjovi M.N., Deravi N., Nariman Z., Gholamzad A., Keylani K., Alizadeh A., Mousavianfard S.R.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/318Введение

Введение. Acinetobacter baumannii (A. baumannii) — это распространенный и исключительно госпитальный микроорганизм, новая мутация которого устойчива к большинству доступных антибиотиков, за исключением тигециклина. Клиницисты выражают озабоченность в связи с недавними данными о резистентности к этому антибиотику, зафиксированными в Иране.

Цель

Цель. Оценить устойчивость Acinetobacter baumannii (A. baumannii) к тигециклину в Иране, учитывая его клиническое значение в лечении инфекций с множественной лекарственной устойчивостью.

Материалы и методы

Материалы и методы. В базах данных MEDLINE, PubMed, Web of Science (WOS), Scopus проведен поиск исследований, опубликованных за все время до января 2024 г. Выполнен расширенный поиск с использованием медицинских тематических рубрик (MeSH) по таким терминам, как «Acinetobacter baumannii», «тигециклин». В соответствии с критериями приемлемости были отобраны название, аннотация и полный текст статей. Также были включены перекрестные исследования, в которых сообщалось об устойчивости к тигециклину у последовательных изолятов A. baumannii среди госпитализированных пациентов иранских клиник.

Результаты

Результаты. В метаанализ было включено в общей сложности 16 исследований. Общая распространенность штаммов A. baumannii, устойчивых к тигециклину, составила 18,1%. Выявлены отчетливые различия в устойчивости. Несмотря на то, что исследования проводились в ограниченном количестве регионов, сообщалось о широком диапазоне резистентности: от минимальной в исследовании в Тегеране (0%) до максимальной в исследовании в Тебризе (100%).

Заключение

Заключение. В результате проведенного исследования установлено, что, несмотря на высокий уровень резистентности в некоторых городах Ирана, тигециклин по-прежнему остается одним из наиболее эффективных антибиотиков для лечения инфекции A. baumannii. Существует вероятность, что, улучшив контроль за применением антибиотиков, можно замедлить или остановить распространение устойчивости к ним.

Introduction

Introduction. Acinetobacter baumannii (A. baumannii) is a widespread and exclusively hospital-acquired microorganism whose new mutation is resistant to most available antibiotics, with the exception of tigecycline. Clinicians are concerned about recent evidence of resistance to this antibiotic in Iran.

Objective

Objective. This study evaluates the resistance of Acinetobacter baumannii (A. baumannii) to tigecycline in Iran, considering its clinical significance in treating multi-drug-resistant infections.

Methods

Methods. The MEDLINE, PubMed, Web of Science (WOS), and Scopus databases were searched for studies published over all this time to January 2024. The advanced search using Medical Subject Headings (MeSH) terms for “Acinetobacter baumannii” and “Tigecycline” was performed. The title, abstract, and full text of the articles were screened based on eligibility criteria. The cross-sectional studies reporting Tigecycline resistance in sequential isolates of A. baumannii in patients admitted to the hospitals in Iran were included.

Results

Results. A total of 16 studies were included for meta-analysis. The overall prevalence of A. baumannii strains resistant to tigecycline in Iran equals 18.1%. Among the reviewed studies, distinct variances of resistance were detected. Although investigations were conducted in limited regions, the studies reported a wide range of resistance in Tehran (0%) and in Tabriz (100%) as minimum and maximum, respectively.

Conclusion

Conclusion. Despite the high level of resistance in some cities of Iran, tigecycline is still one of the most effective antibiotics for the treatment of A. baumannii infection. Improved control over the use of antibiotics may contribute to hampering the spread of resistance to these agents.

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The authors declare that there are no conflicts of interest present.