mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2024.032mes-36Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHВычислительный фантом для дозиметрии красного костного мозга десятилетнего ребенка от инкорпорированных бета-излучателейComputational phantom for the dosimetry of the red bone marrow of a 10-year-old child due to incorporated beta-emittersШарагинП. А.SharaginP. A.

Павел Алексеевич Шарагин

ул. Воровского, д. 68-а, г. Челябинск, 454141

Pavel A. Sharagin

Vorovskogo, 68-а, Chelyabinsk, 454141

sharagin@urcrm.ruТолстыхЕ. И.TolstykhE. I.

ул. Воровского, д. 68-а, г. Челябинск, 454141

Vorovskogo, 68-а, Chelyabinsk, 454141

ШишкинаЕ. А.ShishkinaE. A.

ул. Воровского, д. 68-а, г. Челябинск, 454141

Vorovskogo, 68-а, Chelyabinsk, 454141

Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства РоссииРоссияUrals Research Center for Radiation Medicine of the Federal Medical-Biological AgencyRussian FederationУральский научно-практический центр радиационной медицины Федерального медико-биологического агентства России; Челябинский государственный университетРоссияUrals Research Center for Radiation Medicine of the Federal Medical-Biological Agency; Chelyabinsk State UniversityRussian Federation2024221020242623848Copyright © Шарагин П.А., Толстых Е.И., Шишкина Е.А., 20242024Шарагин П.А., Толстых Е.И., Шишкина Е.А.Sharagin P.A., Tolstykh E.I., Shishkina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/36

Остеотропные радионуклиды, в частности 89,90Sr, могут попадать в окружающую среду при различных техногенных радиационных инцидентах, оттуда с пищей и водой они поступают в организм человека, что приводит к внутреннему облучению красного костного мозга (ККМ). Эти элементы были в составе радиоактивных сбросов в реку Теча в 1950-е гг., и являются основным источником облучения ККМ жителей прибрежных территорий. Оценка доз на ККМ опирается на дозиметрическое моделирование, которое включает разработку трехмерных вычислительных фантомов частей скелета. На основе имитации переноса энергии в этих фантомах оценивают коэффициенты перехода от активности радионуклида в кости к мощности дозы в ККМ. Целью исследования было разработать вычислительный фантом скелета десятилетнего ребенка для оценки доз на ККМ от инкорпорированных бета-излучателей. Для создания фантомов использовали оригинальный SPSD (от англ. stochastic parametric skeletal dosimetry) подход. Согласно данной методике, участки скелета, содержащие ККМ, разбивались на меньшие сегменты простой геометрической формы, для которых генерировались воксельные фантомы. Параметры для генерации фантомов основаны на опубликованных данных, они включали: линейные размеры костей, толщину кортикального слоя, характеристики костной микроархитектуры, плотность и химический состав моделируемых сред и долю содержания ККМ в костях. Сгенерированный вычислительный фантом участков скелета с активным гемопоэзом десятилетнего ребенка состоит из 38 фантомов-сегментов. Линейные размеры сегментов были 3–88 мм, толщина кортикального слоя — 0,2–2,2 мм.

Bone-seeking radionuclides, in particular 89,90Sr, could get into the environment in the course of various anthropogenic radiation incidents. From there they enter a human body with food and water. This leads to red bone marrow (RBM) internal exposure. These elements were present in the composition of radioactive releases into the Techa River in 1950s, and are the major source of RBM exposure for the residents of the riverside settlements. RBM dose estimation relies on dosimetric modeling which comprises the development of 3D computational phantoms of the skeleton parts. By imitating the energy transfer in these phantoms, the conversion coefficients from the radionuclide activity in a bone to the dose rate in RBM are evaluated. The given study is yet another step in the research aimed at the elaboration of a set of computational phantoms of the skeleton for people of various age. The objective is to develop a computational phantom of a skeleton of a 10-year-old child to estimate dose to RBM due to incorporated beta-emitters. Original SPSD (stochastic parametric skeletal dosimetry) approach was used to create the phantoms. According to this method the skeleton sites containing RBM were divided into smaller segment of simple geometric shape, for which voxel phantoms were generated. The parameters for phantom generation were based on published research data. They included^ linear dimensions of bones, thickness of the cortical layer, characteristics/properties of the bone micro-architecture, density and chemical composition of the modelled media and the percentage of RBM content in bones. Generated computational phantom of the skeleton sites with active hematopoiesis of a 10-year-old child consists of 38 phantom-segments. Linear dimensions of the segments were from 3 to 88 mm, cortical layer thickness: 0.2–2.2 mm.

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The authors declare that there are no conflicts of interest present.