mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2025-396mes-396Research ArticleГЛАВНАЯ ТЕМА: МЕДИКО-БИОЛОГИЧЕСКИЕ ВОПРОСЫ РАДИАЦИОННОЙ БЕЗОПАСНОСТИMAIN TOPIC: MEDICAL AND BIOLOGICAL ISSUES IN RADIATION SAFETYВычислительный фантом для дозиметрии красного костного мозга для 15-летних юношей и девушекComputational phantom for red bone marrow dosimetry in 15-year-old adolescentshttps://orcid.org/0000-0002-1457-4916ШарагинП. А.SharaginP. A.

Шарагин Павел Алексеевич

Озерск

Pavel A. Sharagin

Ozersk

sharagin@urcrm.ruhttps://orcid.org/0000-0002-4958-3214ТолстыхЕ. И.TolstykhE. I.

Толстых Евгения Игоревна, д-р биол. наук

Озерск

Evgenia I. Tolstykh, Dr. Sci. (Biol.)

Ozersk

evgenia.tolstykh@yandex.ruhttps://orcid.org/0000-0003-4464-0889ШишкинаЕ. А.ShishkinaE. A.

Шишкина Елена Анатольевна, д-р биол. наук

Озерск; Челябинск

Elena A. Shishkina, Dr. Sci. (Biol.)

Ozersk; Chelyabinsk

lena@urcrm.ruЮжно-Уральский федеральный научно-клинический центр медицинской биофизики Федерального медико-биологического агентстваРоссияSouthern Urals Federal Research and Clinical Center for Medical BiophysicsRussian FederationЮжно-Уральский федеральный научно-клинический центр медицинской биофизики Федерального медико-биологического агентства; Челябинский государственный университетРоссияSouthern Urals Federal Research and Clinical Center for Medical Biophysics; Chelyabinsk State UniversityRussian Federation202610062026282205214Copyright © Шарагин П.А., Толстых Е.И., Шишкина Е.А., 20262026Шарагин П.А., Толстых Е.И., Шишкина Е.А.Sharagin P.A., Tolstykh E.I., Shishkina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/396Введение

Введение. Вычислительные фантомы широко применяются для оценки доз облучения красного костного мозга от остеотропных радионуклидов. Наиболее распространенными такими радионуклидами являются изотопы стронция. Создание фантомов для 89,90Sr требует аккуратного описания формы, размеров и микроархитектуры костей. На сегодняшний день опубликованы описания фантомов новорожденного, годовалого, 5-летних и 10-летних детей, а также взрослых мужчины и женщины. Данное исследование является продолжением работы по созданию цифровых моделей скелета для людей разного пола и возраста.

Цель

Цель. Разработка вычислительных фантомов скелетов 15-летних юношей и девушек для оценки доз в красном костном мозге (ККМ) от инкорпорированных бета-излучающих радионуклидов.

Материалы и методы

Материалы и методы. Для создания фантомов был использован SPSD (stochastic parametric skeletal dosimetry) подход. Были выделены участки скелета с активным гемопоэзом, которые были разделены на сегменты. Параметры моделей сегментов были оценены по данным литературы и включали в себя: характеристики микроструктуры кости, толщину слоя кортикальной кости, размеры костей и их участков, а также долю содержания ККМ, химический состав и плотность моделируемых сред. Также были оценены значения вариабельности этих параметров.

Результаты

Результаты. Разработанные фантомы 15-летних юношей и девушек включают по 46 сегментов; параметры 14 из них различались для юношей и девушек. Размеры фантомов были 3,5–66 мм, а толщина кортикальной кости 0,3–2,3 мм.

Выводы

Выводы. Фантомы, полученные в рамках данной работы, отражают размеры и структуру участков скелета с активным гемопоэзом 15-летних юношей и девушек, учитывают половые различия, а также имитируют вариабельность характеристик скелета.

Introduction

Introduction. Computational phantoms are widely used for assessing radiation doses to the red bone marrow (RBM) from bone-seeking radionuclides. Among them, strontium isotopes are the most common. The development of phantoms for 89,90Sr requires accurate description of bone shape, size, and microarchitecture. To date, phantoms for newborns, one-year-old, five-year-old, and 10-year-old children, as well as for adult males and females, have been proposed. This study is a continuation of our work on creating digital skeletal models for humans of different sexes and ages.

Objective

Objective. Development of computational phantoms for the skeleton for 15-year-old adolescents with the purpose of assessing doses in RBM from incorporated beta-emitting radionuclides.

Materials and methods

Materials and methods. The phantoms were developed using the stochastic parametric skeletal dosimetry (SPSD) approach. Skeletal regions with active hematopoiesis were identified and segmented. The parameters of the segment models were estimated based on literature data, including bone microstructural characteristics, cortical bone layer thickness, bone and segment dimensions, the fractional content of RBM, and the chemical composition and density of the modeled media. The variability ranges of these parameters were also assessed.

Results

Results. The developed phantoms for 15-year-old male and female adolescents comprise 46 segments each; parameters for 14 of these segments differed between males and females. The phantom dimensions ranged 3.5–66 mm; the cortical bone thickness varied 0.3–2.3 mm.

Conclusions

Conclusions. The phantoms developed in this work reflect the dimensions and structure of skeletal regions with active hematopoiesis in 15-year-old adolescents, account for sexual dimorphism, and simulate the variability of skeletal characteristics.

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The authors declare that there are no conflicts of interest present.