mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2025-403mes-403Research ArticleАВИАЦИОННАЯ И КОСМИЧЕСКАЯ МЕДИЦИНАAVIATION & SPACE MEDICINEВзаимосвязь кардиомаркеров NT-proBNP и ST2 с функциональными параметрами сердечно-сосудистой системы в условиях антиортостатической гипокинезииInterrelationship of NT-proBNP and ST2 cardiac biomarkers with cardiovascular functional parameters under conditions of head-down bed resthttps://orcid.org/0009-0002-3749-588XПоповаО. В.PopovaO. V.

Попова Ольга Владимировна

Москва

Olga V. Popova

Moscow

olya.popovaolga2710@yandex.ruhttps://orcid.org/0000-0002-9646-7275КаширинаД. Н.KashirinaD. N.

Каширина Дарья Николаевна, канд. биол. наук

Москва

Daria N. Kashirina, Cand. Sci. (Biol.)

Moscow

daryakudryavtseva@mail.ruhttps://orcid.org/0009-0009-5891-3500СтуловаЛ. С.StulovaL. S.

Стулова Лидия Сергеевна

Москва

Lidiia S. Stulova

Moscow

lidastulova@gmail.comhttps://orcid.org/0000-0002-2071-0443ПастушковаЛ. Х.PastushkovaL. K.

Пастушкова Людмила Ханифовна, д-р биол. наук

Москва

Liudmila K. Pastushkova, Dr. Sci. (Biol.)

Moscow

lpastushkova@mail.ruhttps://orcid.org/0009-0005-9117-9521ЛаринаИ. М.LarinaI. M.

Ларина Ирина Михайловна, д-р мед. наук

Москва

Irina M. Larina, Dr. Sci. (Med.)

Moscow

irina.larina@gmail.comhttps://orcid.org/0000-0001-6658-8079РусановВ. Б.RusanovV. B.

Русанов Василий Борисович, д-р биол. наук

Москва

Vasily B. Rusanov, Dr. Sci. (Biol.)

Moscow

rusvb@imbp.ruИнститут медико-биологических проблем РАНРоссияInstitute of Biomedical Problems of the Russian Academy of SciencesRussian Federation202610062026282315321Copyright © Попова О.В., Каширина Д.Н., Стулова Л.С., Пастушкова Л.Х., Ларина И.М., Русанов В.Б., 20262026Попова О.В., Каширина Д.Н., Стулова Л.С., Пастушкова Л.Х., Ларина И.М., Русанов В.Б.Popova O.V., Kashirina D.N., Stulova L.S., Pastushkova L.K., Larina I.M., Rusanov V.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/403Введение

Введение. Гиподинамия является одним из ключевых факторов риска сердечно-сосудистых заболеваний. Одной из моделей изучения данного состояния является антиортостатическая гипокинезия (АНОГ), которая позволяет исследовать патофизиологические изменения в сердце. Эксперименты с АНОГ выявили структурные изменения в сердце: снижение артериального давления, нарушение вегетативной регуляции и ремоделирование сосудов. Однако молекулярные механизмы этих процессов остаются малоизученными.

Цель

Цель. Изучение связи функциональных параметров сердечно-сосудистой системы с кардиомаркерами NT-proBNP и ST2.

Материалы и методы

Материалы и методы. В эксперименте участвовали 6 испытателей-добровольцев, которые находились в условиях 21-суточной антиортостатической гипокинезии. Проведен анализ вариабельности сердечного ритма (ВСР), дисперсионного картирования (ДК ЭКГ), а также уровня NT-proBNP и концентрации белка ST2 в образцах венозной крови. Исследования выполнены за 5 дней до начала АНОГ, на 1, 10, 20 сут в условиях АНОГ и на 5 сут после экспериментального воздействия. Все вычисления были выполнены с помощью статистического программного пакета Statistica 12.

Результаты

Результаты. Было показано, что концентрация белка NT-proBNP достоверно снижалась на 10 и 20 сут эксперимента, концентрация белка ST2 уменьшалась уже с первых суток гипокинезии. Показатель деполяризация левого желудочка резко возрастал в середине исследования, но возвращался к исходным значениям к 5 сут после завершения воздействия. Симпатическая активность повышалась к 20 сут.

Выводы

Выводы. Установлены взаимосвязи между функциональными параметрами сердечно-сосудистой системы и кардиомаркерами, которые могут указывать на то, что АНОГ вызывает активацию нейрогуморального и метаболического контуров регуляции на фоне повышения симпатических вегетативных модулирующих эффектов.

Introduction

Introduction. Insufficient physical activity is a key risk factors in the development of cardiovascular diseases. Such a condition can be simulated by head-down tilt bed rest (HDBR) studies, which enable the investigation of pathophysiological changes in the heart. Previous HDBR experiments have identified structural alterations in the heart, including decreased arterial pressure, impaired autonomic regulation, and vascular remodeling. However, the molecular mechanisms underlying these processes remain poorly understood.

Objective

Objective. To investigate links between functional parameters of the cardiovascular system and NT-proBNP and ST2 cardiac biomarkers.

Materials and methods

Materials and methods. The experiment involved six volunteers who were subjected to 21-day HDBR. The parameters of heart rate variability (HRV), dispersion mapping (ECG DM), as well as levels of NT-proBNP and ST2 protein concentrations in venous blood samples, were evaluated. The examination was conducted five days before the onset of HDBR, on Days 1, 10, and 20 during HDBR, and on Day 5 after the experimental exposure. All computations were performed using the Statistica 12 statistical software package.

Results

Results. The NT-proBNP protein concentration significantly decreased on Days 10 and 20 of the experiment, while the ST2 protein concentration was permanently decreasing from the first days of HDBR. The left ventricular depolarization index increased sharply in the middle of the study, although having returned to their baseline values by Day 5 after the cessation of the exposure. Sympathetic activity had increased by Day 20.

Conclusions

Conclusions. Interrelationships between functional parameters of the cardiovascular system and cardiac biomarkers were established, which may indicate that HDBR triggers the activation of neurohumoral and metabolic regulatory circuits in the setting of increased sympathetic autonomic modulating effects.

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The authors declare that there are no conflicts of interest present.