mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2023.061mes-45Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHВычислительный фантом для дозиметрии красного костного мозга пятилетнего ребенка от инкорпорированных бета-излучателейComputational phantom for a 5-year old child red bone marrow dosimetry due to incorporated beta emittersШарагинП. А.SharaginP. А.

Челябинск

Chelyabinsk 

ТолстыхЕ. И.TolstykhE. I.

Челябинск

Chelyabinsk 

ШишкинаЕ. А.ShishkinaE. A.

Челябинск

Chelyabinsk 

Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства РоссииРоссияUrals Research Center for Radiation Medicine of the Federal Medical-Biological AgencyRussian FederationУральский научно-практический центр радиационной медицины Федерального медико-биологического агентства России; Челябинский государственный университетРоссияUrals Research Center for Radiation Medicine of the Federal Medical-Biological Agency; Chelyabinsk State UniversityRussian Federation2023231020242548697Copyright © Шарагин П.А., Толстых Е.И., Шишкина Е.А., 20242024Шарагин П.А., Толстых Е.И., Шишкина Е.А.Sharagin P.А., Tolstykh E.I., Shishkina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/45

Облучение ККМ (красного костного мозга) остеотропными радионуклидами может приводить к серьезным медицинским последствиям. В частности, увеличение риска развития лейкозов у людей, подвергшихся радиационному воздействию в результате загрязнения реки Течи в 1950-е гг., связано с облучением ККМ от 89,90Sr. Совершенствование методов внутренней дозиметрии ККМ включает разработку вычислительных фантомов, которые представляют собой трехмерные модели участков скелета. Моделирование переноса излучений внутри таких фантомов позволяет оценить коэффициенты перехода от активности радионуклида в кости к мощности дозы в ККМ. Настоящая статья — продолжение работы по созданию набора вычислительных фантомов скелета для людей разного возраста. Цель: разработать вычислительный фантом скелета пятилетнего ребенка для внутренней дозиметрии ККМ от инкорпорированных бета-излучателей. Фантомы участков скелета с активным гемопоэзом создавали с использованием оригинальной методики SPSD (stochastic parametric skeletal dosimetry). В рамках этой методики каждый такой участок представлял собой набор меньших фантомов простой геометрической формы. Распределение ККМ в скелете, размеры костей, характеристики костной микроархитектуры, а также плотность и химический состав моделируемых сред (ККМ, кость) определяли на основе опубликованных данных. В результате был сгенерирован вычислительный фантом основных участков скелета с активным гемопоэзом для пятилетнего ребенка, включающий 43 фантома участков костей. Линейные размеры фантомов были в пределах от 3 мм до 75 мм. Параметры микроархитектуры варьировали в широких пределах: отношение BV/TV — от 13% до 52%, Tb. Th. — от 0,09 мм до 0,29 мм, Tb. Sp. — от 0,48 мм до 0,98 мм.

The red bone marrow (RBM) exposure due to bone-seeking radionuclides can lead to grave medical consequences. In particular, the increased risk of leukemia in people exposed due to contamination of the Techa River in 1950s is associated with the RBM exposure due to 89,90Sr. Improvement of the internal RBM dosimetry methods includes the development of computational phantoms that represent 3D models of the skeletal sites. Modeling radiation transport within such phantoms enables estimation of conversion factors from the radionuclide activity in the bone to the RBM dose rate. This paper is an extension study focused on generating a set of computational phantoms representing skeletons of individuals of different ages. The aim was to develop a computational phantom representing a 5-year- old child for internal RBM dosimetry from incorporated beta emitters. The phantoms of the skeletal sites with active hematopoiesis were created using the original Stochastic Parametric Skeletal Dosimetry (SPSD) method. With this method, every such site represented a set of smaller phantoms of simple geometric shape. RBM distribution across the skeleton, bone size, characteristics of bone micro-architecture, as well as density and chemical composition of the simulated media (RBM, bone) were determined based on the published data. As a result, a computational phantom of the major skeletal sites with active hematopoiesis representing a 5-year-old child was generated that included 43 phantoms of bone fragments. Linear dimensions of phantoms were within 3–75 mm. Micro-architecture parameters varied greatly: BV/TV ratio —13–52%, Tb. Th. — 0.09–0.29 mm, Tb. Sp. —0.48–0.98 mm.

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The authors declare that there are no conflicts of interest present.