mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2024.019mes-67Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHВегетативная регуляция кровообращения и биоэлектрические процессы в миокарде человека в моделируемых гипомагнитных условияхVegetative regulation of blood circulation and bioelectric processes in the human myocardium under simulated hypomagnetic conditionsПоповаО. В.PopovaO. V.

Ольга Владимировна Попова

Хорошевское шоссе, 76А, г. Москва, 123007

Olga V. Popova

Khoroshevskoye shosse, 76А, Moscow, 123007

olya.popovaolga2710@yandex.ruРусановВ. Б.RusanovV B.

Хорошевское шоссе, 76А, г. Москва, 123007

Khoroshevskoye shosse, 76А, Moscow, 123007

ОрловО. И.OrlovO. I.

Хорошевское шоссе, 76А, г. Москва, 123007

Khoroshevskoye shosse, 76А, Moscow, 123007

Государственный научный центр Российской Федерации — Институт медико-биологических проблем Российской академии наукРоссияState Scientific Center of the Russian Federation — Institute for Biomedical Problems of the Russian Academy of SciencesRussian Federation20242310202426294101Copyright © Попова О.В., Русанов В.Б., Орлов О.И., 20242024Попова О.В., Русанов В.Б., Орлов О.И.Popova O.V., Rusanov V.B., Orlov O.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/67

На сегодняшний день становится актуальной перспектива длительных межпланетных полетов, поэтому необходимо понимание изменений в сердечно- сосудистой системе (ССС), которые будут происходить в гипомагнитных условиях. Целью исследования было провести анализ изменений механизмов ССС, которые представляют собой основу для формирования вариабельности сердечного ритма и биоэлектрических процессов в миокарде, в условиях сниженного в 350, 650 и 1000 раз магнитного поля Земли. В эксперименте (2023 г.) участвовало 6 мужчин-добровольцев в возрасте 26–37 лет, у которых непрерывно в течение 32 ч регистрировали электрокардиограмму. Анализ полученных данных проводили при помощи кластерного и дисперсионного анализа. Было обнаружено, что у мужчин-добровольцев, относящихся к группе с преобладанием парасимпатических влияний, функционального резерва хватает для критических значений (воздействия сниженного магнитного поля до 1000 раз). У добровольцев с преобладанием симпатических моделирующих влияний поддержание приспособительных реакций осуществляется метаболическим регуляторным контуром. В этой группе реакция на воздействие сниженного магнитного поля достаточно выражена при пороге его снижения от 350 раз. Проведенный нами пилотный эксперимент, отражающий влияние сниженного магнитного поля земли на ССС, имеет определяющее значение для разработки концепции последующих экспериментальных воздействий, связанных с редукцией магнитного поля, для интересов космической физиологии и медицины.

Today, the prospect of long-term interplanetary missions becomes relevant, that is why it is necessary to understand the changes in the cardiovascular system (CVS) that would occur in hypomagnetic environment. The study was aimed to assess the changes in the CVS mechanisms underlying formation of heart rate variability and bioelectric processes in the myocardium under conditions the 350-, 650-, and 1000-fold reduced Earth’s magnetic field. The experiment (2023) involved 6 male volunteers aged 26–37 years, in whom electrocardiography was continuously performed throughout 32 h. The data obtained were assessed by cluster analysis and analysis of variance. It was found than male volunteers, who belonged to the group showing predominance of parasympathetic effects, had enough functional reserve for critical values (exposure to the up to 1000-fold reduced magnetic field). In volunteers showing predominance of sympathetic modulatory effects, the adaptive response maintenance was ensured by the metabolic regulatory circuit. In this group, the response to the reduced magnetic field exposure was quite pronounced at the threshold of its 350-fold reduction. Our pilot experiment reflecting the effect of the reduced Earth’s magnetic field on the CVS is crucial for development of the concept of further experimental exposures related to magnetic field reduction benefiting space physiology and medicine.

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The authors declare that there are no conflicts of interest present.