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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mes</journal-id><journal-title-group><journal-title xml:lang="ru">Экстремальная биомедицина</journal-title><trans-title-group xml:lang="en"><trans-title>Extreme Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">3033-8964</issn><issn pub-type="epub">3033-8972</issn><publisher><publisher-name>Centre for Strategic Planning of the Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47183/mes.2024.020</article-id><article-id custom-type="elpub" pub-id-type="custom">mes-74</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Вопрос сохранения интериктальной активности в длительных ЭЭГ-исследованиях эпилепсии</article-title><trans-title-group xml:lang="en"><trans-title>The issue of preserving interictal activityin long-term EEG studies of epilepsy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуляев</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gulyaev</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергей Александрович Гуляев</p><p>ул. Раменки, д. 31, к. 136, г. Москва, 119607</p></bio><bio xml:lang="en"><p>Sergey A. Gulyaev</p><p>Ramenki, 31, k. 136, Moscow, 119607</p></bio><email xlink:type="simple">sergruss@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климанов</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimanov</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Раменки, д. 31, к. 136, г. Москва, 119607</p></bio><bio xml:lang="en"><p>Ramenki, 31, k. 136, Moscow, 119607</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гермашев</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Germashev</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Раменки, д. 31, к. 136, г. Москва, 119607</p></bio><bio xml:lang="en"><p>Ramenki, 31, k. 136, Moscow, 119607</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ханухова</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Khanukhova</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Раменки, д. 31, к. 136, г. Москва, 119607</p></bio><bio xml:lang="en"><p>Ramenki, 31, k. 136, Moscow, 119607м</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гармаш</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Garmash</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ул. Раменки, д. 31, к. 136, г. Москва, 119607</p></bio><bio xml:lang="en"><p>Ramenki, 31, k. 136, Moscow, 119607м</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Инженерно-физический институт биомедицины НИЯУ МИФИ; Клиника Ла Салюте</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Engineering and Physical Institute of Biomedicine, National Research Nuclear University MEPhI; La Salute Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Инженерно-физический институт биомедицины НИЯУ МИФИ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Engineering and Physical Institute of Biomedicine, National Research Nuclear University MEPhI</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Клиника Ла Салюте</institution><country>Россия</country></aff><aff xml:lang="en"><institution>La Salute Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>23</day><month>10</month><year>2024</year></pub-date><volume>26</volume><issue>2</issue><fpage>140</fpage><lpage>145</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гуляев С.А., Климанов С.Г., Гермашев Г.А., Ханухова Л.М., Гармаш А.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Гуляев С.А., Климанов С.Г., Гермашев Г.А., Ханухова Л.М., Гармаш А.А.</copyright-holder><copyright-holder xml:lang="en">Gulyaev S.A., Klimanov S.G., Germashev G.A., Khanukhova L.M., Garmash A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.extrememedicine.ru/jour/article/view/74">https://www.extrememedicine.ru/jour/article/view/74</self-uri><abstract><p>Современное применение математических методов анализа ЭЭГ-записей ограничено из-за феномена усреднения информации. В этих условиях актуально найти наиболее вероятный метод повышения качества диагностики пароксизмальных патологических паттернов, имеющих малую продолжительность «жизни», таких как вспышки и субклинические пароксизмы. Целью исследования было оценить возможность исключения межприступной интериктальной активности из длительного ЭЭГ-исследования для достижения его информационного «обогащения» путем формирования условной последовательностей патологических изменений, представляющих его главную клиническую задачу. Было обследовано 40 человек разного возраста, обоих полов. В контрольную группу вошли 20 пациентов 12–67 лет с непосредственным выявлением спайк-волновой активности на ЭЭГ. Группу сравнения составили 20 пациентов 10–66 лет с отсутствием спайк-волновой активности в записи. Показано, что интериктальные данные, полученные у пациентов c наличием эпилептиформных феноменов, не представляют значимого интереса для основной группы клинических исследований. Исключение этих данных приводит к «обогащению» информации и за счет последовательного размещения пароксизмальных паттернов позволяет получать не только более компактные результаты обследований патологической составляющей, но и сформировать базу для разработок с использованием технологий их последующего математического анализа.</p></abstract><trans-abstract xml:lang="en"><p>Modern application of mathematical methods for analyzing EEG recordings is limited due to the phenomenon of information averaging. In these conditions, it is important to find the most likely method for improving the quality of diagnosis of paroxysmal pathological patterns that have a short “life”, such as outbreaks and subclinical paroxysms. The purpose of the study was to evaluate the possibility of excluding interictal activity from a long-term EEG study in order to achieve its information “enrichment” by forming conditional sequences of pathological changes representing its main clinical task. Forty people of different ages and both sexes were examined. The control group included 20 patients aged 12–67 years with direct detection of spike-wave activity on the EEG. The comparison group consisted of 20 patients aged 10–66 years with no spike-wave activity in the recording. It has been shown that interictal data obtained in patients with epileptiform phenomena are not of significant interest for the main group of clinical studies. The exclusion of these data leads to the “enrichment” of information due to the sequential placement of paroxysmal patterns and makes it possible to obtain not only more compact results of examinations of the pathological component, but also to form a basis for developments using technologies for their subsequent mathematical analysis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>электроэнцефалография</kwd><kwd>продолженные ЭЭГ-исследования</kwd><kwd>анализ результатов</kwd><kwd>нагрузка на врача</kwd></kwd-group><kwd-group xml:lang="en"><kwd>electroencephalography</kwd><kwd>continued EEG studies</kwd><kwd>analysis of results</kwd><kwd>workload on the doctor</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cascino GD. Video-EEG monitoring in adults. Epilepsia. 2002; 43 Suppl 3: 80–93. DOI: 10.1046/j.1528–1157.43.s.3.14.x. 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