mesЭкстремальная биомедицинаExtreme Medicine3033-89643033-8972Centre for Strategic Planning of the Federal Medical and Biological Agency10.47183/mes.2023.008mes-77Research ArticleОБЗОРREVIEWРасчет референтных интервалов для показателей крови у детей и подростков: обзор проектовCalculation of reference intervals of blood parameters in children and adolescents: projects reviewГришинаЖ. В.GrishinaZh. V.

Жанна Валерьевна Гришина 

ул. Б. Дорогомиловская, д. 5, г. Москва, 121059 

Zhanna V. Grishina 

B. Dorogomilovskaya, 5, Moscow, 121059 

grinzanetk@gmail.comКлючниковС. О.KlyuchnikovS. O.

Москва 

Moscow 

ФещенкоВ. С.FeshchenkoV. S.

Москва 

Moscow 

ЖолинскийА. В.ZholinskiyA. V.

Москва 

Moscow 

Федеральный научно-клинический центр спортивной медицины и реабилитации Федерального медико-биологического агентстваРоссияFederal Research and Clinical Center of Sports Medicine and Rehabilitation of the Federal Medical Biological AgencyRussian Federation202324102024251411Copyright © Гришина Ж.В., Ключников С.О., Фещенко В.С., Жолинский А.В., 20242024Гришина Ж.В., Ключников С.О., Фещенко В.С., Жолинский А.В.Grishina Z.V., Klyuchnikov S.O., Feshchenko V.S., Zholinskiy A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.extrememedicine.ru/jour/article/view/77

В обзоре существующих на сегодняшний день проектов по расчету референтных интервалов показателей крови на больших выборках детей разного пола и возраста обсуждены актуальные вопросы расчета педиатрических референтных интервалов для биохимических маркеров, проведено сравнение значений референтных интервалов, полученных в разных проектах. Представлены ограничения, будущие перспективы и гармонизация педиатрических референтных интервалов, в том числе для несовершеннолетних спортсменов.

The review of the currently existing projects focused on calculating the reference intervals of blood parameters in large samples of children of different gender and age discusses the urgent issues of calculating pediatric reference intervals of biochemical markers, the paper provides comparison of the reference intervals established within the framework of different projects. The limitations, future prospects and harmonization of pediatric reference intervals, including for juvenile athletes, are provided.

референтные интервалыпоказатели кровипедиатриядетинесовершеннолетние спортсменыспортивная медицинаreference intervalsblood parameterspediatricschildrenjuvenile athletessports medicineРабота выполнена в рамках прикладной научно-исследовательской работы по теме: «Разработка методических рекомендаций по повышению эффективности мероприятий медико-биологического обеспечения несовершеннолетних спортсменов спортивных сборных команд Российской Федерации» (шифр «Дети-22»), государственный контракт ФГБУ ФНКЦСМ ФМБА России № 107.002.22.14 от 11.07.2022.The study was performed as part of the applied research project “Developing the Guidelines on Increasing the Efficiency of the Measures for Medical and Biological Support of Juvenile Athletes of Russian National Teams” (code “Deti-22”), the Federal Research and Clinical Center of Sports Medicine and Rehabilitation of the Federal Medical Biological Agency State Assignment №107.002.22.14 of 11.07.2022.ReferencesДёмин В. Ф., Ключников С. 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The authors declare that there are no conflicts of interest present.