Morphological characteristics of toxic brain damage
https://doi.org/10.47183/mes.2024.025
Abstract
The effects of various toxicants on the body tissues cause tissue abnormalities resulting in dystrophic changes and necrosis. The nervous system is the most vulnerable to the effects of exogenic substances, both chemical and biological, due to high metabolic activity and the cells' incapability of self-renewal. Neurotoxicants lead to disturbances of cellular nutrition and eventually to neurodegeneration. Neurons can die due to both apoptosis and necrosis.
Supporting agencies: The study was conducted as part of the State Assignment of the FMBA of Russia No. 388-00071-24-00 (theme code 64.004.24.800) and supported by the State Assignment of the Sechenov Institute of Evolutionary Physiology and Biochemistry RAS No. 075-00264-24-00.
About the Authors
O. N. Gaikova
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
A. A. Kozlov
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
G. G. Katretskaya
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
M. V. Melnikova
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
A. S. Melekhova
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
A. A. Bondarenko
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
Yu. O. Sokolova
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
E. D. Bazhanova
Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Bekhtereva, 1, Saint-Petersburg; 192019
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Review
For citations:
Gaikova O.N., Kozlov A.A., Katretskaya G.G., Melnikova M.V., Melekhova A.S., Bondarenko A.A., Sokolova Yu.O., Bazhanova E.D. Morphological characteristics of toxic brain damage. Extreme Medicine. 2024;26(2):13-19. https://doi.org/10.47183/mes.2024.025
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