Перспективы терапии рака молочной железы с использованием онколитических вирусов
https://doi.org/10.47183/mes.2021.044
Аннотация
Рак молочной железы (РМЖ) — онкологическое заболевание с высокой распространенностью и смертностью среди женщин во всем мире. Диагностика РМЖ не столь эффективна для выявления заболевания на ранних стадиях, а терапевтические методы связаны с тяжелыми побочными эффектами. Онколитические вирусы могут стать новым эффективным средством в терапии РМЖ. Их эффективность обусловлена двумя типами воздействия на раковую опухоль: непосредственным уничтожением опухолевых клеток и запуском противоопухолевого иммунного ответа. Повысить эффективность терапии онколитическими вирусами можно путем конструирования генетически-модифицированных вирусов, обладающих лучшей селективностью к опухолевым клеткам молочной железы и (или) способных к большему усилению противоопухолевого иммунного ответа. Представлены дальнейшие направления применения онколитических вирусов в терапии РМЖ, оптимальные пути доставки вирусов в опухоль и эффективность их использования в комбинации с другими терапевтическими средствами (методами), а также перспектива использования онколитических вирусов в качестве противоопухолевых вакцин.
Ключевые слова
Об авторе
А. В. Благов
Центр стратегического планирования Федерального медико-биологического агентства
Россия
Россия
Александр Владимирович Благов,
д. 5, к. 6, ул. Щукинская, г. Москва, 123182.
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Рецензия
Для цитирования:
Благов А.В. Перспективы терапии рака молочной железы с использованием онколитических вирусов. Медицина экстремальных ситуаций. 2021;23(4):34-41. https://doi.org/10.47183/mes.2021.044
For citation:
Blagov A.V. Recombinant adeno-associated viruses as a gene delivery vehicle for the use in molecular medicine. Extreme Medicine. 2021;23(4):34-41. https://doi.org/10.47183/mes.2021.044
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