Clinical and virological characteristics of chronic hepatitis b and response to antiviral therapy
https://doi.org/10.47183/mes.2023.003
Abstract
Chronic hepatitis B (CHB) is a common infectious disease that represents one of the main causes of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). CHB is still difficult to treat due to the lack of drugs that completely eliminate hepatitis B virus (HBV) from hepatocytes. The study was aimed to describe the CHB clinical and laboratory features, assess the efficiency of antiviral therapy and identify the factors associated with the response to antiviral therapy. The results of clinical and laboratory assessment, instrumental examination, serological and molecular testing of the patients (n = 201) followed up between 2007–2021 in the Viral Hepatitis Diagnosis and Treatment Center at the Clinical Hospital No. 85 of FMBA of Russia were assessed based on primary sources. Most of the patients in the group were males (56.7%); the HBeAg-negative patients predominated (93%). LC was diagnosed in nine patients (4.5%), among them one patient had HCC. The HBV D genotype was determined in 95.4% of cases, А genotype in 3.1% of cases, and С genotype in 1.5% of cases. After a year of treatment with the nucleos(t)ide analogues (entecavir or tenofovir) 88% of patients showed no viremia and their biochemical parameters were back to normal (88%). The overall seroconversion rate was 41.7% for HBeAg and 3% for HBsAg. Thus, high rates of virological response and enzyme activity normalization were obtained. Low baseline viremia level is an independent prognostic factor of achieving a virological response. The HBsAg level in the end of therapy makes it possible to predict relapse after the treatment cessation.
About the Authors
Thi-Hanh Nguyen
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Nguyen Thi-Hanh
Akademika Volgina, 39, Moscow, 117437
L. I. Melnikova
Clinical hospital № 85 of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Moscow
L. Yu. Ilchenko
Pirogov Russian National Research Medical University ; Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products
Russian Federation
Russian Federation
Moscow
K. K. Kyuregyan
Mechnikov Research Institute of Vaccines and Sera
Russian Federation
Russian Federation
Moscow
I. V. Gordeychuk
Chumakov Federal Scientific Center for Research and Development of Immune and Biological Products
Russian Federation
Russian Federation
Moscow
N. L. Bondarenko
Clinical hospital № 85 of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Nguyen T., Melnikova L.I., Ilchenko L.Yu., Kyuregyan K.K., Gordeychuk I.V., Bondarenko N.L. Clinical and virological characteristics of chronic hepatitis b and response to antiviral therapy. Extreme Medicine. 2023;25(1):59-67. https://doi.org/10.47183/mes.2023.003
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