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Clinical features of protracted intestinal infection associated with Klebsiella pneumoniae in an infant

https://doi.org/10.47183/mes.2024.006

Abstract

The development of complex criteria for the diagnosis, differential diagnosis, and optimization of treatment of infectious diarrhea associated with opportunistic Enterobacteriaceae is a pressing issue of pediatric research and practice. The paper reports a clinical case of protracted intestinal infection associated with Klebsiella pneumoniae in the form of moderate hemorrhagic enterocolitis in an infant, which is explained by the decrease in specific resistance due to unfavorable maternal obstetric and gynecological history, perinatal CNS injury, iron deficiency anemia, protein-energy malnutrition. The disease relapse associated with secondary norovirus infection was reported after the first hospitalization. Three courses of intestinal antiseptics and probiotics were required to achieve a beneficial treatment outcome, although usually in such a situation one course of such drugs is enough. The recovery process was accompanied by the nutritional status improvement, hemorrhagic colitis relief, normalization of gut microbiota.

About the Authors

N. V. Gonchar
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical Biological Agency; Mechnikov North-Western State Medical University
Russian Federation

Natalia V. Gonchar

Kazanskaya, 45, Saint Petersburg, 190000



A. K. Kopersak
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical Biological Agency
Russian Federation

Moscow



N. V. Skripchenko
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical Biological Agency; Saint Petersburg State Pediatric Medical University
Russian Federation

Moscow

Saint Petersburg



I. V. Razdyakonova
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical Biological Agency
Russian Federation

Moscow



Yu. A. Podlipnaya
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical Biological Agency
Russian Federation

Moscow



References

1. Lanata FC, Fisher-Walker CL, Olascoaga AC, Torres CX, Aryee MJ, Blanck RE. Global causes of diarrheal disease mortality in children <5 years of age: a systematic review. PLoS One. 2013; 8 (9): e72788.

2. Gosudarstvennyy doklad «O sostoyanii sanitarnoepidemiologicheskogo blagopoluchiya naseleniya v Rossiyskoy Federatsii v 2022 godu». M.: Federal'naya sluzhba po nadzoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka, 2023; 368 p. Russian.

3. Kharchenko GA, Kimirilova OG. Clinical and epidemiological features of acute intestinal infections caused by opportunistic enterobacteria in young children. Lechaschy Vrach. 2021; 4 (24): 37–41. Russian.

4. Mustaeva GB. Features of the course of Klebsiella infection according to the Samarkand regional clinical hospital. 2020; 18–2 (96): 81–5. Russian.

5. Kuzmenko SA, Brusina EB. Medical technologies affecting the infection of children with Klebsiella bacteria, infection prevention. Chronos. 2020; 8 (46): 39–43. Russian.

6. Pronko NV, Krasko YuP. Clinical and epidemiological features of Klebsiella infection in children at the present stage. Actual Infectology. 2019; 7 (3): 155–9. Russian.

7. Shrestha A, Six J, Dahal D, Marks S, Meierhofer R. Association of nutrition, water, sanitation and hygiene practices with children's nutritional status, intestinal parasitic infections and diarrhea in rural Nepal: a cross-sectional study. BMC Public Health. 2020; 20 (1): 1241. PubMed PMID: 32799826.

8. Klimova OI, Gonchar NV, Lobzin YuV. Faktory riska formirovaniya funktsional'nykh gastrointestinal'nykh rasstroystv posle infektsionnykh gemokolitov u detey. University therapeutic journal (Universitetskiy terapevticheskiy vestnik). Sbornik materialov III Rossiysk. gastroenterol. kongressa «Gastroenterologiya Rossii ot rozhdeniya do starosti (pediatricheskie, terapevticheskie, khirurgicheskie i mediko-sotsial'nye aspekty)». 2020; 2 (1): 60–2. Russian.

9. Mashina SE, Malyavina TE, Targonskiy SN, Mukhina ON, Sharypova MG. Otsenka effektivnosti preparata Reaferon-ESlipint v kompleksnoy terapii infektsionnykh enterokolitov u detey pervogo goda zhizni. Poliklinika. 2015; 1–2: 97–9. Russian.

10. González-Fernández D, Cousens S, Rizvi A, Chauhadry I, Soofi SB, Bhutta ZA. Infections and nutrient deficiencies during infancy predict impaired growth at 5 years: Findings from the MAL-ED study in Pakistan. Front Nutr. 2023; 17 (10): 1104654. PubMed PMID: 36875830.

11. Vitetta L, Vitetta G, Yall S. Immunological tolerance and function: associations between intestinal bacteria, probiotics, prebiotics, and phages. Frontiers in Immunology. 2018; 9: 2240. PubMed PMID: 30356736.

12. Gorelov AV, Petrov VA, Rodionova NV. Choice of paediatric medical nutrition in intestinal infections. Medical Council. 2021; 1: 143–7. Russian.

13. Gonchar NV, Skripchenko NV. Promising areas of scientific research on the problems of intestinal infections. Children's medicine of the North-West. 2023; 11 (2): 50–61. Russian.

14. Eberlin M, Chen M, Muec T, Däbritz J. Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. BMC Pediatrics. 2018; 18: 124. DOI: 10.1186/s12887-018-1095-x.


Review

For citations:


Gonchar N.V., Kopersak A.K., Skripchenko N.V., Razdyakonova I.V., Podlipnaya Yu.A. Clinical features of protracted intestinal infection associated with Klebsiella pneumoniae in an infant. Extreme Medicine. 2024;26(1):112-118. https://doi.org/10.47183/mes.2024.006

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ISSN 2713-2757 (Print)
ISSN 2713-2765 (Online)