Глобальные и национальные регистры доноров костного мозга: опыт использования, основные трудности и перспективы

В статье обобщен ряд представленных в зарубежной литературе сведений, касающихся общих организационно-методических аспектов функционирования регистров доноров костного мозга и гемопоэтических стволовых клеток, проблематики HLA-типирования, технических алгоритмов ранжирования степени совместимости. Описаны изменения мотивационной сферы граждан в ответ на программы популяризации донорства костного мозга, особенности организации рекрутинга, подходы к определению требований к численности регистра с учетом многонациональности и неоднородности этнического состава и алгоритмы их статистической аппроксимации. Кроме того, уделено внимание так называемым специальным организационно- методическим аспектам функционирования регистров и биобанков костного мозга и гемопоэтических стволовых клеток. Последнее важно с точки зрения обеспечения национальной безопасности, адаптации населения к последствиям катастроф, чрезвычайных происшествий и террористических акций, сопровождающихся развитием у большого числа пострадавших костномозговой формы лучевой болезни.

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